Ovarian cancer risk in Polish BRCA1 mutation carriers is not associated with the prohibitin 3' untranslated region polymorphism

Table 2 Association of the PHB_1630_C > T polymorphism with ovarian cancer risk in BRCA1 carriers

	All cases and controls
Genotype	Cases (n = 127) n (%)	Controls (n = 127) n (%)	OR_crude ^b (95% CI)	p
PHB_1630_C > T
CC	101 (80)	102 (80)	1.00 (reference)
CT+TT^a	26 (20)	25 (20)	1.05 (0.54–2.04)	1.00
	Cases and controls with risk factor information
Genotype	Cases (n = 83) n (%)	Controls (n = 83) n (%)	OR_adj ^c (95% CI)	p
PHB_1630_C > T
CC	64 (77)	65 (78)	1.00(reference)
CT+TT^a	19 (23)	18 (18)	1.34 (0.59–3.11)	0.49

^a Due to the low proportion of <3% in patients and controls, CT and TT genotypes were combined.
^b OR_crude: crude odds ratio.
^c OR_adj: odds ratio adjusted for age at menarche, age of first live birth, parity, breastfeeding, OC use, HRT, smoking and BMI.

ISSN: 1471-2407