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Table 1 Plasma MMP1 and MMP8 levels in relation to standard prognostic markers.

From: Plasma MMP1 and MMP8 expression in breast cancer: Protective role of MMP8 against lymph node metastasis

Characteristics

MMP1 (ng/ml)

OR (95% CI)

p*

MMP8 (ng/ml)

OR (95% CI)

p*

 

Median (IQR)

n

  

Median (IQR)

n

  

all patients

2.0 (0.8–3.7)

202

  

10.5 (4.4–19.1)

198

  

menopausal status

        

premenopausal

2.0 (0.5–4.0)

70

1.02 (0.91–1.13)

0.67

14.8 (5.4–20.8)

70

0.98 (0.95–1.00)

0.06

postmenopausal

2.0 (1.0–3.5)

122

  

10.0 (4.2–18.8)

117

  

unknown

2.2 (1.3–3.0)

10

  

6.0 (3.6–13.4)

11

  

breast cancer

        

inflammatory

1.1 (0.6–2.0)

21

0.74 (0.56–0.98)

0.02

6.3 (3.5–8.5)

19

0.90 (0.83–0.97)

0.007

non-inflammatory

2.2 (0.8–3.9)

181

  

11.0 (4.7–20.5)

179

  

non-inflammatory breast cancer patients

        

Primary tumour size

        

pT1

2.4 (1.1–4.2)

79

1.11 (1.00–1.23)

0.07

10.2 (3.8–20.5)

76

0.99 (0.97–1.01)

0.14

pT2

2.2 (0.8–3.7)

76

  

11.0 (4.6–18.8)

77

  

pT3

1.3 (0.6–2.2)

26

  

16.4 (6.4–24.0)

26

  

axillary lymph node status

        

pN0

2.3 (1.1–4.1)

86

1.04 (0.94–1.15)

0.18

7.5 (3.5–19.1)

83

0.99 (0.97–1.01)

0.003

pN1

1.9 (0.8–3.6)

67

  

13.4 (8.0–22.5)

66

  

pN2

0.9 (0.1–3.4)

19

  

18.0 (12.5–22.0)

19

  

pN3

2.7 (1.9–4.6)

9

  

5.7 (2.9–8.9)

11

  

histologic grade

        

well (G1)

3.4 (1.0–4.6)

17

0.99 (0.90–1.10)

0.14

4.9 (3.3–20.9)

16

1.00 (0.98–1.03)

0.37

moderatly (G2)

1.6 (0.6–3.0)

70

  

15.2 (4.8–21.6)

68

  

poorly (G3)

2.2 (1.1–4.0)

94

  

11.0 (5.4–18.9)

95

  

oestrogen receptor

        

Negative

1.6 (0.2–3.7)

21

1.13 (0.92–1.39)

0.31

8.9 (4.3–22.9)

22

1.00 (0.97–1.04)

0.93

Positive

2.2 (0.9–4.0)

160

  

11.3 (5.1–20.1)

157

  

progesteron receptor †

        

Negative

2.0 (0.2–3.5)

32

1.13 (0.95–1.35)

0.29

12.3 (4.9–23.5)

32

0.98 (0.95–1.00)

0.30

Positive

2.2 (0.9–4.0)

148

  

10.9 (4.7–19.4)

146

  

Her2 overexpression

        

Negative

2.2 (0.8–3.8)

158

0.97 (0.82–1.14)

0.79

10.9 (4.9–20.2)

156

1.03 (1.00–1.06)

0.39

Positive

1.8 (1.1–4.4)

23

  

13.7 (3.2–25.7)

23

  
  1. *p for Mann-Whitney U test or Kruskal-Wallis test. † Progesteron receptor status is unknown for one patient in both MMP1 and MMP8 analyses.
  2. Note: Her2 status was defined by immunohistochemistry and dual-colour FISH analyses
  3. IQR, interquartile range; OR, odds ratio