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Table 3 Immunohistochemical features of 123 cases of invasive mammary carcinomas according to axillary lymph node status

From: Lymph vascular invasion in invasive mammary carcinomas identified by the endothelial lymphatic marker D2-40 is associated with other indicators of poor prognosis

IHC features Mac-Met n (%) Mic-Met n (%) LNN n (%) Total n (%)
ER *     
Positive 31 (75.6) 35 (85.4) 34 (82.9) 100 (81.3)
Negative 10 (24.4) 6 (14.6) 7 (17.1) 23 (18.7)
PR *     
Positive 25 (61) 29 (70.7) 28 (68.3) 82 (66.7)
Negative 16 (39) 12 (29.3) 13 (31.7) 41 (33.3)
Her2/ neu score     
0 and 1+ 35 (85.4) 32 (78) 36 (87.8) 103 (83.7)
2+ 1 (2.4) 1 (2.4) 1 (2.4) 3 (2.4)
3+ 5 (12.2) 8 (19.5) 4 (9.8) 17 (13.8)
P53     
Positive 17 (41.5) 11 (26.8) 10 (24.4) 38 (30.9)
Negative 24 (58.5) 30 (73.2) 31 (75.6) 85 (69.1)
Ki67 score *     
<10% 16 (39) 23 (56.1) 16 (39) 55 (44.7)
10–25% 11 (26.8) 9 (22) 13 (31.7) 33 (26.8)
25–50% 10 (24.4) 6 (14.6) 8 (19.5) 24 (19.5)
>50% 4 (9.8) 3 (7.3) 4 (9.8) 11 (8.9)
E-cadherin score     
0 (negative) 2 (4.9) 1 (2.4) 2 (4.9) 5 (4.1)
1+ 3 (7.3) 3 (7.3) 2 (4.9) 8 (6.5)
2+ 0 (0) 2 (4.9) 1 (2.4) 3 (2.4)
3+ 8 (19.5) 6 (14.6) 4 (9.8) 18 (14.6)
4+ 28 (68.3) 29 (70.7) 32 (78) 89 (72.4)
Total 41 (100) 41 (100) 41 (100) 123 (100)
  1. Mac-Met = macrometastases; Mic-Met = micrometastases; LNN = lymph node negative; n = number of cases; IHC = immunohistochemical; ER = estrogen receptor; PR = progesterone receptor
  2. * Tumors with lymphatic invasion showed an increased Ki67 score (p = 0.00013), but lower estrogen (p = 0.0016) and progesterone (p = 0.00017) receptor scores. This correlation with lymphatic invasion was significant in H&E-sections and also in IHC-sections.
  3. The other variables showed no statistical significant correlations with LVI identified either by H&E or IHC-sections.