Do genetic factors protect for early onset lung cancer? A case control study before the age of 50 years

BMC Cancer

Table 4 Genetic association estimates and smoking for GPX1(Pro200Leu) and EPHX1(His113Tyr)

			Relative chance for LC compared to ...
			Genetic protected never or light smokers *		Genetic protected of the same smoking exposure*.^§
SEL: smoking exposure level	Genetic disposition	n cases:controls	OR	95% CI	OR	95% CI
*GPX1(Pro200Leu)*
Never and light smoker	CC	11:53	*1.0*	*Reference*	*1.0*	*Reference*
	T-carrier	5:42	0.9	0.3 – 3.0	0.9	0.3 – 3.0
Moderate smoker	CC	30:9	18.4	6.1 – 55.8	*1.0*	*Reference*
	T-carrier	15:12	10.1	3.4 – 30.2	0.6	0.2 – 1.6
Heavy smoker	CC	86:9	70.1	24.5 – 200	*1.0*	*Reference*
	T-carrier	52:16	22.1	8.3 – 59.3	0.3	0.1 – 0.8
*EPHX1(His113Tyr)*
Never and light smoker	TT	1:10	*1.0*	*Reference*	*1.0*	*Reference*
	C-carrier	18:88	1.4	0.5 – 4.1	1.4	0.5 – 4.1
Moderate smoker	TT	4:2	40.0	12.2 – 131	*1.0*	*Reference*
	C-carrier	58:19	11.1	4.0 – 31.2	0.2	0.1 – 0.7
Heavy smoker	TT	14:2	58.2	20.9 – 161	*1.0*	*Reference*
	C-carrier	153:23	45.5	16.6 – 124	0.8	0.3 – 1.9

* odds ratio. adjusted for sex and age
^§ odds ratio of allele carriers compared to non carriers within the same smoking group
SEL smoking exposure level: never and light smokers: ≤1 pack years. moderate smokers: 1-<20 pack years. heavysmokers: ≥20 pack years.

ISSN: 1471-2407