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Table 2 Correlation between combined FOXP3+ T-reg and B7-H1 with the clinicopathological parameters of 62 breast cancer patients

From: FOXP3+ Tregs and B7-H1+/PD-1+T lymphocytes co-infiltrate the tumor tissues of high-risk breast cancer patients: Implication for immunotherapy

  FOXP3 and B7-H1 Expression *P
  Both + One + Both -  
Age     
< 40 years 21 (55) 7 (18) 10 (26) 0.496
≥ 40 years 10 (45) 7 (32) 5 (23)  
Tumor Size     
<4 cm 18 (64) 6 (21) 4 (14) 0.128
≥ 4 cm 13 (41) 8 (25) 11 (34)  
Lymph Node Metastasis     
Negative 12 (63) 3 (16) 4 (21) 0.605
1 to 3 4 (33) 3 (25) 5 (42)  
4 to 9 9 (50) 5 (28) 4 (22)  
10 or more 5 (56) 3 (33) 1 (11)  
Histological Grade (SBR)     
II 9 (30) 7 (23) 14 (47) <0.001
III 22 (73) 7 (23) 1 (3)  
Lymphovascular Invasion     
Positive 20 (56) 8 (22) 8 (2) 0.745
Negative 11 (46) 6 (25) 7 (29)  
Her2/neu Status     
Positive 16 (57) 7 (25) 5 (18) 0.487
Negative 15 (47) 7 (22) 10 (31)  
ER Status     
Positive 16 (40) 10 (25) 14 (35) 0.017
Negative 15 (75) 4 (20) 1 (5)  
PR Status     
Positive 11 (38) 7 (24) 11 (38) 0.054
Negative 20 (65) 7 (23) 4 (13)  
Neo-adjuvant Chemotherapy     
With 17 (49) 9 (26) 9 (26) 0.828
Without 14 (56) 5 (20) 6 (24)  
Lymphocyte Infiltration     
Focal 10 (38) 5 (19) 11 (42) 0.022
Moderate 9 (47) 7 (37) 3 (16)  
Severe 12 (80) 2 (13) 1 (7)  
  1. Abbreviations: (+ and -) are number of positive and negative patients, Numbers between brackets are the percentages of patients, Two sample had unknown LN+ status, *P values in bold represent a significant data.