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Table 3 Gene-environment interaction stratified by gender. Haplotype-specific effects of average smoking intensity and consumption of alcohol on the risk of colorectal cancer

From: A haplotype of polymorphisms in ASE-1, RAI and ERCC1and the effects of tobacco smoking and alcohol consumption on risk of colorectal cancer: a danish prospective case-cohort study

Haplotype   Men Women
  Carriera N cases/sub-cohort IRRb CI (95%)c Pd N cases/sub-cohort IRRb CI (95%)c Pd
Smoking intensitye (per 10 g tobacco/day) No 130/232 0.93 0.76–1.13 0.26 62/149 1.58 0.99–2.50 0.42
  Yes 45/74 1.14 0.79–1.63   31/52 1.23 0.64–2.38  
  missing 3/8     4/4    
Alcohol intakef (per 10 g/day) No 164/313 1.04 0.97–1.12 0.15 121/276 1.15 0.98–1.36 0.17
  Yes 51/104 1.20 1.00–1.43   47/80 0.87 0.61–1.25  
  missing 3/13     7/6    
  1. a) Homozygous carriers of the haplotype compared to the rest. Homozygous carrier of the previously identified haplotype consisting of ERCC1 Asn118AsnTT, ASE-1 G-21AGG and RAI IVS1 A4364GAA
  2. b) IRR: incidence rate ratio
  3. c) CI: 95% confidence interval
  4. d) P: test for interaction
  5. e) Risk estimates for ever smokers only. Adjusted for smoking status (present/former/never), intake of alcohol, fruits/vegetables, fish/poultry, red and processed meat, dietary fibres, BMI and hormone replacement therapy.
  6. f) Risk estimates for alcohol consumers only. Adjusted for average smoking intensity, fruits/vegetables, fish/poultry, red and processed meat, dietary fibres, BMI and hormone replacement therapy