A haplotype of polymorphisms in ASE-1, RAI and ERCC1and the effects of tobacco smoking and alcohol consumption on risk of colorectal cancer: a danish prospective case-cohort study

Table 3 Gene-environment interaction stratified by gender. Haplotype-specific effects of average smoking intensity and consumption of alcohol on the risk of colorectal cancer

Haplotype		Men				Women
	Carrier^a	N _{cases/sub-cohort}	IRR^b	CI (95%)^c	P^d	N _{cases/sub-cohort}	IRR^b	CI (95%)^c	P^d
Smoking intensity^e (per 10 g tobacco/day)	No	130/232	0.93	0.76–1.13	0.26	62/149	1.58	0.99–2.50	0.42
	Yes	45/74	1.14	0.79–1.63		31/52	1.23	0.64–2.38
	missing	3/8				4/4
Alcohol intake^f (per 10 g/day)	No	164/313	1.04	0.97–1.12	0.15	121/276	1.15	0.98–1.36	0.17
	Yes	51/104	1.20	1.00–1.43		47/80	0.87	0.61–1.25
	missing	3/13				7/6

a) Homozygous carriers of the haplotype compared to the rest. Homozygous carrier of the previously identified haplotype consisting of ERCC1 Asn118Asn^TT, ASE-1 G-21A^GG and RAI IVS1 A4364G^AA
b) IRR: incidence rate ratio
c) CI: 95% confidence interval
d) P: test for interaction
e) Risk estimates for ever smokers only. Adjusted for smoking status (present/former/never), intake of alcohol, fruits/vegetables, fish/poultry, red and processed meat, dietary fibres, BMI and hormone replacement therapy.
f) Risk estimates for alcohol consumers only. Adjusted for average smoking intensity, fruits/vegetables, fish/poultry, red and processed meat, dietary fibres, BMI and hormone replacement therapy

ISSN: 1471-2407