ERCC22251A>C genetic polymorphism was highly correlated with early relapse in high-risk stage II and stage III colorectal cancer patients: A preliminary study

Table 4 Correlation between gene polymorphism and clinicopathological properties of 201 postoperative colorectal cancer patients

		GSTP1		ABCB1		MTHFR		TYMS		ERCC2		XRCC1
Characteristics	Total cases (n)	AA	AG or GG	CC	CT or TT	CC	CT or TT	3R3R	2R3R or 2R2R	AA	AC or CC	GG	GA or AA
Gender
Male	118	73	45	46	72	68	50	79	39	102	16	73	45
Female	83	56	27	24	59	54	29	56	27	74	9	51	32
		P = 0.414		P = 0.140		P = 0.228		P = 0.938		P = 0.566		P = 0.952
Age (yr)
>60	120	76	44	39	81	76	44	80	40	102	18	74	46
51~60	48	28	20	20	28	27	21	32	16	42	6	33	15
≤50	33	25	8	11	22	19	14	23	10	32	1	17	16
		P = 0.293		P = 0.520		P = 0.643		P = 0.944		P = 0.182		P = 0.293
Tumor Size
<5 cm	107	67	40	37	70	67	40	72	35	94	13	71	36
≥5 cm	94	62	32	33	61	55	39	63	31	82	12	53	41
		P = 0.622		P = 0.938		P = 0.552		P = 0.968		P = 0.895		P = 0.147
Location
Colon	146	96	50	52	94	86	60	96	50	127	19	89	57
Rectum	55	33	22	18	37	36	19	39	16	49	6	35	20
		P = 0.448		P = 0.701		P = 0.397		P = 0.488		P = 0.687		P = 0.728
Depth of tumor invasion
T2	26	19	7	9	17	15	11	17	9	22	4	18	8
T3 + T4	175	110	65	61	114	107	68	118	57	154	21	106	69
		P = 0.311		P = 0.981		P = 0.737		P = 0.836		P = 0.626		P = 0.397
Lymph node metastasis
Negative	110	68	42	41	69	65	45	75	35	95	15	66	44
Positive	91	61	30	29	62	57	34	60	31	81	10	58	33
		P = 0.443		P = 0.423		P = 0.608		P = 0.736		P = 0.571		P = 0.588
Stage^a
II	105	64	41	41	64	62	43	71	34	91	14	63	42
III	96	65	31	29	67	60	36	64	32	85	11	61	35
		P = 0.318		P = 0.189		P = 0.617		P = 0.886		P = 0.687		P = 0.606

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