Flow-cytometric monitoring of disease-associated expression of 9-O-acetylated sialoglycoproteins in combination with known CD antigens, as an index for MRD in children with acute lymphoblastic leukaemia: a two-year longitudinal follow-up study

Table 2 Sensitivity and specificity of the templates used for the detection of MRD in children with ALL

*Cell surface antigen	¹Sensitivity (%)	²Specificity (%)	³Detection level of MRD
OAcSGP	100	100	Till 5%
CD19	84.27	100
CD10	58.43	100
CD34	25.8	100
CD3	15.7	100
CD7	15.7	100
OAcSGP, CD19	84.27	100	Till 0.1%
OAcSGP, CD10	58.43	100
OAcSGP, CD34	25.8	100
OAcSGP, CD3	15.7	100
OAcSGP, CD7	15.7	100
CD19, CD10	58.43	100
CD19, CD34	25.8	100
CD3, CD7	15.7	100
OAcSGP, CD10, CD19	58.43	100	Till 0.01%
OAcSGP, CD34, CD19	25.8	100
OAcSGP, CD7, CD3	15.7	100

* Single or a combination (double or triple colour) of cell surface antigen/s used for the MRD assay
¹ Probability of a positive test among patients with disease
² Probability of a negative test among patients without disease
³ Detection level of the presence of diseased cells in the patient

ISSN: 1471-2407