|
BAC ID
|
Chrom. region
|
Candidate Gene
|
Frequency of DCNAs(%)
|
Frequency of DCNAs(%)
|
P-value*
|
|---|
|
Gain
| | | | | |
|
Node metastasis
| | |
Positive (n = 60)
|
Negative (n = 23)
| |
|
225
|
2q24.32
|
TMEM132D
|
3
|
26
|
0.0005
|
|
1308
|
5q13.2
|
FCHO2, MGC13034
|
7
|
43
|
0.0005
|
|
491
|
16p13.11
|
PKD1P3
|
5
|
35
|
0.0006
|
|
884
|
19q13.32
|
N.i.
|
5
|
30
|
0.0006
|
|
Liver metastasis
| | |
Positive (n = 6)
|
Negative (n = 77)
| |
|
1322
|
1p13.2
|
CHIA, C1orf88, OVGP1
|
43
|
3
|
<0.0001
|
|
1271
|
8p22
|
N.i.
|
67
|
13
|
0.0016
|
|
92
|
11p15
|
ST5
|
43
|
6
|
0.0006
|
|
Peritoneal dissemination
| | |
Positive (n = 19)
|
Negative (n = 64)
| |
|
948
|
15q22.1
|
MYO1E, LDHAL6B
|
22
|
0
|
0.0002
|
|
155
|
Xp21.2
|
XK
|
35
|
5
|
0.0009
|
|
Histologic type
| | |
Diffuse (n = 42)
|
Intestinal (n = 41)
| |
|
563
|
10p15.3
|
DIP2C
|
7
|
38
|
0.0011
|
|
911
|
10q24.2
|
SPFH1, CHUK, CWF19L1
|
0
|
23
|
0.0013
|
|
Loss
| | | | | |
|
Node metastasis
| | |
Positive (n = 60)
|
Negative (n = 23)
| |
|
936
|
8p21.2
|
DOCK5, GNRH1, KCTD9, CDCA2
|
3
|
23
|
0.0023
|
|
1158
|
8p21.1
|
EXTL3
|
3
|
21
|
0.0023
|
|
878
|
13q31.2
|
SLITRK5
|
13
|
47
|
0.0007
|
|
Liver metastasis
| | |
Positive (n = 6)
|
Negative (n = 77)
| |
|
877
|
1p32.3
|
LRP8,
|
50
|
5
|
0.0006
|
|
1386
|
7q35
|
CNTNAP2,
|
43
|
4
|
0.0001
|
|
309
|
21q22.3
|
HSF2BP, KIAA0179,
|
29
|
1
|
0.0002
|
|
Peritoneal dissemination
| | |
Positive (n = 19)
|
Negative (n = 64)
| |
|
1407
|
3p26.3
|
CNTN6
|
33
|
6
|
0.0009
|
|
503
|
3p24.3
|
UBE2E1
|
32
|
6
|
0.0009
|
|
229
|
4q31.1
|
MAML3
|
44
|
5
|
<0.0001
|
|
Histologic type
| | |
Diffuse (n = 42)
|
Intestinal (n = 41)
| |
|
1292
|
4q34.1
|
N.i.
|
17
|
53
|
0.0004
|
|
1393
|
5q33.2
|
TIMD4
|
15
|
48
|
0.0007
|
|
91
|
8p21.3
|
INTS10
|
0
|
24
|
0.0006
|
|
227
|
14q32.33
|
IGHV3-22
|
16
|
54
|
0.0001
|
|
1122
|
15q15.3
|
GANC, CAPN3
|
2
|
27
|
0.0003
|
|
1210
|
17q13.2
|
ATP2A3, ZZEF1
|
5
|
41
|
0.0001
|
- N.I.; not identified
- * χ2 test between two groups
- Ratios (log2) that exceed >0.25 are considered DNA copy number gains, and ratios (log2) that exceed <-0.25 are considered to be DNA copy number losses.
