Table 2 Twenty genes that were identified as upregulated in tumors of the high SUV group compared with those of the low SUV group
Rank | Symbol | Gene name | Genbank Accession No. | High/Low ratioa) | Function |
|---|---|---|---|---|---|
1 | CENPF | centromere protein F (mitosin) | NM016343 | 3.66 | cell-cycle regulation |
2 | CDC6 | cell division cycle 6 | NM001254 | 3.36 | cell-cycle regulation |
3 | gtf2b | general transcription factor IIB | M76766 | 2.79 | transcription initiation |
4 | Fgr | Gardner-Rasheed feline sarcoma viral oncogene homolog | NM005248 | 2.49 | mast cell activation |
5 | GAPDHS | glyceraldehyde-3-phosphate_dehydrogenase | NM002046 | 2.18 | carbohydrate metabolism |
6 | Oaz1 | ornithine decarboxylase 1 | NM002539 | 2.14 | regulation of polyamine synthesis |
7 | ACTA1 | actin, alpha 2, smooth muscle, aorta | NM001613 | 2.1 | cell motility, structure |
8 | KRT5 | keratin 5 | NM000424 | 2.05 | type 2 cytokeratine |
9 | RCC1 | chromosome condensation 1 | NM001269 | 2.03 | cell-cycle regulation |
10 | BAK1 | BCL2-antagonist/killer 1 | NM001188 | 1.96 | anti- or pro-apoptotic regulators |
11 | MMP9 | matrix metalloproteinase 9 | NM004994 | 1.95 | embryonic development and tissue remodeling |
12 | MAP2K5 | mitogen-activated protein kinase kinase 5 | NM002757 | 1.94 | Kinase related to signal cascade |
13 | MAP2K2 | mitogen-activated protein kinase kinase 2 | NM030662 | 1.93 | Kinase related to signal cascade |
14 | Litaf | LPS-induced TNF-alpha factor | NM004862 | 1.9 | proinflammatory cytokine |
15 | COL7A1 | collagen, type VII, alpha 1 | NM000094 | 1.85 | epithelial adhesion complex |
16 | HRMT1L2 | HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2 | NM001536 | 1.84 | catalyzes protein methyl-transferase modification |
17 | CXCL13 | small inducible cytokine B subfamily, member 13 | NM006419 | 1.82 | migration of B lymphocytes |
18 | PLAU | plasminogen activator, urokinase | NM002658 | 1.78 | serine protease |
19 | CDC37 | cell division cycle 37 | NM007065 | 1.77 | cell-cycle regulation |
20 | Pax | paxillin | NM002859 | 1.74 | cell adhesion of the extracellular matrix |