Table 1 Expression of class I HDAC isoforms in renal cell carcinoma stratified for selected tumour parameters

All Cases

106

(100%)

47

(44.3%)

59

(55.7%)

46

(43.4%)

60

(56.6%)

92

(86.8%)

14

(13.2%)

Age ≤ 61

49

(46.2%)

23

(46.9%)

26

(53.1%)

0.696⁺

19

(38.8%)

30 (61.2%)

0.434⁺

42

(85.7%)

7

(14.3%)

0.781⁺

Age >61

57

(53.8%)

24

(42.1%)

33

(57.9%)

27

(47.4%)

30 (52.6%)

50

(87.7%)

7

(12.3%)

pT1

53

(50.0%)

20

(37.7%)

33

(62.3%)

0.088*

19

(35.8%)

34

(64.2)

0.088*

43

(81.1%)

10

(18.9)

0.052*

pT2

3

(2.8%)

0

(0.0%)

3

(100.0%)

0

(0.0%)

3

(100.0%)

2

(66.7%)

1

(33.3%)

pT3

47

(44.4%)

25

(53.2%)

22

(46.8%)

26

(55.3%)

21 (44.7%)

44

(93.6%)

3

(6.4%)

pT4

3

(2.8%)

2

(66.7%)

1

(33.3%)

1

(33.3%)

2

(66.7%)

3

(100.0%)

0

(0.0%)

Grading G1

11

(10.4%)

6

(54.5%)

5

(45.5%)

0.596*

1

(9.1%)

10 (90.9%)

0.207*

10

(90.9%)

1

(9.1%)

0.602*

Grading G2

74

(69.8%)

33

(44.6%)

41

(55.4%)

42

(56.8%)

32 (43.2%)

64

(86.5%)

10

(13.5%)

Grading G3

17

(16.0%)

6

(35.3%)

11

(64.7%)

3

(17.6%)

14

(82.4%)

15

(88.2%)

2

(11.8%)

Grading G4

4

(3.8%)

2

(50.0%)

2

(50.0%)

0

(0.0%)

4

(100.0%)

3

(75.0%)

1

(25.0%)

pN0 ^#

50

(47.2%)

27

(54.0%)

23

(46.0%)

0.335⁺

26

(52.0%)

24

(48.0%)

0.339⁺

44

(88.0%)

6

(12.0%)

1.000⁺

pN1/2

12

(11.3%)

4

(33.3%)

8

(66.7%)

4

(33.3%)

8

(66.7%)

11

(91.7%)

1

(8.3%)

M0

83

(78.3%)

37

(44.6%)

24

(55.4%)

0.559⁺

37

(44.6%)

46

(55.4%)

0.412⁺

72

(86.7%)

11

(13.3%)

.642⁺

M1

23

(21.7%)

10

(43.5%)

13

(56.5%)

9

(39.1%)

14

(60.9)

20

(87.0%)

3

(13.0%)

HDAC1 low

47

(44.3%)

-

-

-

31 (66.0%)

16

(34.0%)

<0.001⁺

43

(91.5%)

4

(8.5%)

0.255⁺

HDAC1 high

59

(55.7%)

-

-

15

(25.4%)

44 (74.6%)

49

(83.1%)

10

(16.9%)

HDAC2 low

46

(43.4%)

31

(67.4%)

15

(32.6%)

<0.001⁺

-

-

-

45

(97.8%)

1

(2.2%)

0.003⁺

HDAC2 high

60

(56.6%)

16

(26.7%)

44

(73.3%)

-

-

47

(78.3%)

13

(21.7%)

HDAC3 low

92

(86.8%)

43

(46.7%)

49

(53.3%)

0.255⁺

45

(48.9%)

47

(51.1%)

0.003⁺

-

-

-

HDAC3 high

14 (13.2%)

4

(28.6%)

10

(71.4%)

1

(7.1%)

13 (92.9%)

-

-

Ki-67 index ≤ 10%

70

(66.0%)

38

(54.3%)

32

(45.7%)

0.007⁺

37

(52.9%)

33

(47.1%)

0.007⁺

64

(91.4%)

6

(8.6%)

0.068⁺

Ki-67 index > 10%

36

(34.0%)

9

(25.0%)

27

(75.0%)

9

(25.0%)

27

(75.0%)

28

(77.8%)

8

(22.2%)