Figure 1

Inhibition of HSG tumor cell adhesion to neural cells. A, various concentrations of cimetidine were added, and the interaction of HSG cells with neural cells was examined. Phase-contrast microscopic pictures of representative experiments are shown. The number of HSG cells adhering to the neural cell monolayer was counted and is shown in the bar graph. B, NCAM antibody was added and the interaction of HSG cells with neural cells was examined. Phase-contrast microscopic pictures of representative experiments are shown. The number of HSG cells adhering to the neural cell monolayer was counted and is shown in the bar graph. The label 'HSG (treated with MAb NCAM)-neural cell interaction' and the black column in the graph indicate the number of HSG cells adhering to the neural cells when the HSG cells were preincubated with the MAb NCAM. The label 'HSG-neural cell (treated with MAb NCAM) interaction' and the gray column in the graph indicate the number of HSG cells adhering to the neural cells when the neural cells were preincubated with the MAb NCAM. ICAM-1 antibody was also added, and the results are shown as a label 'HSG (treated with MAb ICAM-1)-neural cell interaction' and in the diagonally shaded column (n = 3 experiments; means ± SD).