Figure 4
From: Increased p38-MAPK is responsible for chemotherapy resistance in human gastric cancer cells
Inhibition of p38 MAPK increases SGC7901/VCR to chemotherapy. SGC7901/VCR cells were treated with indicated concentrations of cisplatin, 5-FU or epirubicin, with or without SB202190 (10 μM), for 24 hours. (A) The morphology of cells was observed, and photographs were taken under the microscope. (B) Flow cytometry analysis was performed after staining with Annexin V/PI. Compared with the control cells (without SB202190), there were significantly more apoptotic cells in the SB230920 treatment group. A representative example of an experiment that was repeated three times is shown.