Figure 2

Sensitivity of CAFs to cytotoxic chemotherapy in vitro is highly variable. Primary CAF cell strains from 9 breast and 28 lung tumors and a panel of 22 tumor cell lines as a reference were cultivated in the presence or absence of different doses of paclitaxel (left panel) or cisplatinum (right panel). Cell growth was measured by means of MTT. Each dot represents the drug concentration to achieve 50% inhibition of cell growth (GI50) in one CAF cell strain or cell line.