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Table 2 Relationship between chromosome 7 polysomy and EGFR copy number/EGFR protein expression

From: Analysis of EGFR, HER2, and TOP2A gene status and chromosomal polysomy in gastric adenocarcinoma from Chinese patients

Chromosome 7 copy number

EGFR FISH

EGFR IHC

 

Negative

Positive

Negative

Positive

Non-polysomy

74

7

48

33

Polysomy

10

9

10

9

Total

84

16

58

42

P value

<0.0001*

>0.0026#

Odds ratio

8.2286

1.3091

  1. *: association between chromosome 7 polysomy and EGFR copy number(p < 0.0001), significant after Bonferroni correction;
  2. #: association between chromosome 7 polysomy and EGFR protein expression (p > 0.0026).
  3. EGFR FISH Positive: EGFR high polysomy and amplification. EGFR FISH Negative:EGFR disomy, low trisomy, high trisomy, and low polysomy
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