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Table 1 Clinical and pathological characteristics of patients from the training and validation sets

From: Risk estimation of distant metastasis in node-negative, estrogen receptor-positive breast cancer patients using an RT-PCR based prognostic expression signature

  Training Validation
Characteristics n = 142 n = 279
  n (%) n (%)
Age   
   <40 9 (6.4) 20 (7.2)
   40 – 49 18 (12.8) 74 (26.5)
   50 – 59 28 (19.9) 77 (27.6)
   60 – 69 48 (34.0) 73 (26.2)
   ≥ 70 38 (27.0) 35 (12.5)
   Missing 1 0
   Median 64 yrs (SD 12.6) 55 yrs (SD 11.7)
   Min. – Max. 31 – 89 yrs 29 – 87 yrs
Tumor diameter   
   ≤ 2 cm 126 (94.0) 168 (60.2)
   > 2 cm 8 (6.0) 111 (39.8)
   Missing 8 0
   Median 1.2 cm (SD 0.50) 2 cm (SD 0.85)
   Min. – Max. 0.3 – 2.9 cm 0.0* – 3.0 cm
Tumor grade   
   Grade 1 74 (53.2) 60 (21.5)
   Grade 2 61 (43.9) 166 (59.5)
   Grade 3 4 (2.9) 53 (19.0)
   Missing 3 0
Stage   
   I 126 (94.0) 168 (60.2)
   IIA 8 (6.0) 111 (39.8)
   Missing 8 0
HER2   
   Negative na 251 (93.0)
   Positive na 19 (7.0)
   Missing   9
Surgery   
   Breast conserving na 112 (40.1)
   Mastectomy na 167 (59.9)
Radiotherapy   
   Yes na 115 (39.7)
   No na 175 (60.3)
Distant recurrence   
   Yes 31 (21.8) 71 (25.5)
   No 111 (78.2) 208 (74.6)
Death of all cause   
   Yes 56 (39.4) 134 (48.0)
   No 86 (60.6) 145 (52.0)
Median follow up 8.7 yrs 15.6 yrs
  1. *tumors were impalpable
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