| Cases | Controls | OR (95% CI) | P-value | OR (95% CI)* | P-value |
---|---|---|---|---|---|---|
All women | (n = 209) | (n = 209) | Â | Â | Â | Â |
Allele frequencies | Â | Â | Â | Â | Â | Â |
LEPR (Gln) | 0.49 | 0.51 | Â | Â | Â | Â |
LEPR (Arg) | 0.51 | 0.49 | Â | Â | Â | Â |
Genotype frequencies | Â | Â | Â | Â | Â | Â |
LEPR (Gln/Gln) | 46 (22.0) | 56 (26.8) | 1.0 | Â | Â | Â |
LEPR (Gln/Arg) | 107 (51.2) | 107 (51.2) | 1.2 (0.8–2.0) | 0.42 | 1.2 (0.8–2.0) | 0.40 |
LEPR (Arg/Arg) | 56 (26.8) | 46 (22.0) | 1.5 (0.8–2.6) | 0.16 | 1.6 (0.9–3.2.8) | 0.13 |
LEPR (Gln/Gln | 46 (22.0) | 56 (26.8) | 1.00 | Â | Â | Â |
LEPR (Gln/Arg) + (Arg/Arg) | 163 (78.0) | 153 (73.2) | 1.3 (0.8–2.0) | 0.26 | 1.3 (0.8–2.1) | 0.23 |
Pre-menopausal women | (n = 114) | (n = 121) | Â | Â | Â | Â |
Allele frequencies | Â | Â | Â | Â | Â | Â |
LEPR (Gln) | 0.46 | 0.54 | Â | Â | Â | Â |
LEPR (Arg) | 0.54 | 0.46 | Â | Â | Â | Â |
Genotype frequencies | Â | Â | Â | Â | Â | Â |
LEPR (Gln/Gln) | 23 (20.2) | 38 (31.4) | 1.00 | Â | Â | Â |
LEPR (Gln/Arg) | 60 (52.6) | 54 (44.6) | 1.8 (1.0–3.5) | 0.06 | 1.8 (0.9–3.3) | 0.07 |
LEPR (Arg/Arg) | 31 (27.2) | 29 (24.0) | 1.8 (0.9–3.6) | 0.12 | 1.8 (0.8–3.7) | 0.14 |
LEPR (Gln/Gln | 23 (20.2) | 38 (31.4) | 1.00 | Â | Â | Â |
LEPR (Gln/Arg) + (Arg/Arg) | 91 (79.8) | 83 (68.6) | 1.8 (1.0–3.3) | 0.05 | 1.8 (1.0–3.2) | 0.07 |
Postmenopausal women | (n = 95) | (n = 88) | Â | Â | Â | Â |
Allele frequencies | Â | Â | Â | Â | Â | Â |
LEPR (Gln) | 0.49 | 0.51 | Â | Â | Â | Â |
LEPR (Arg) | 0.51 | 0.49 | Â | Â | Â | Â |
Genotype frequencies | Â | Â | Â | Â | Â | Â |
LEPR (Gln/Gln) | 23 (24.2) | 18 (20.5) | 1.00 | Â | Â | Â |
LEPR (Gln/Arg) | 47 (49.5) | 53 (60.2) | 0.7 (0.3–1.4) | 0.33 | 0.7 (0.4–1.5) | 0.42 |
LEPR (Arg/Arg) | 25 (26.3) | 17 (19.3) | 1.2 (0.5–2.8) | 0.75 | 1.2 (0.5–3.0) | 0.62 |
LEPR (Gln/Gln | 23 (24.2) | 18 (20.5) | 1.00 | Â | Â | Â |
LEPR (Gln/Arg) + (Arg/Arg) | 72 (75.8) | 70 (79.5) | 0.8 (0.4–1.6) | 0.54 | 0.9 (0.4–1.8) | 0.68 |