Skip to main content

Table 1 Distribution of Leptin receptor (LEPR) alleles and genotypes in relation to breast cancer risk (unconditional logistic regression)

From: Leptin receptor Gln223Arg polymorphism and breast cancer risk in Nigerian women: A case control study

  Cases Controls OR (95% CI) P-value OR (95% CI)* P-value
All women (n = 209) (n = 209)     
Allele frequencies       
LEPR (Gln) 0.49 0.51     
LEPR (Arg) 0.51 0.49     
Genotype frequencies       
LEPR (Gln/Gln) 46 (22.0) 56 (26.8) 1.0    
LEPR (Gln/Arg) 107 (51.2) 107 (51.2) 1.2 (0.8–2.0) 0.42 1.2 (0.8–2.0) 0.40
LEPR (Arg/Arg) 56 (26.8) 46 (22.0) 1.5 (0.8–2.6) 0.16 1.6 (0.9–3.2.8) 0.13
LEPR (Gln/Gln 46 (22.0) 56 (26.8) 1.00    
LEPR (Gln/Arg) + (Arg/Arg) 163 (78.0) 153 (73.2) 1.3 (0.8–2.0) 0.26 1.3 (0.8–2.1) 0.23
Pre-menopausal women (n = 114) (n = 121)     
Allele frequencies       
LEPR (Gln) 0.46 0.54     
LEPR (Arg) 0.54 0.46     
Genotype frequencies       
LEPR (Gln/Gln) 23 (20.2) 38 (31.4) 1.00    
LEPR (Gln/Arg) 60 (52.6) 54 (44.6) 1.8 (1.0–3.5) 0.06 1.8 (0.9–3.3) 0.07
LEPR (Arg/Arg) 31 (27.2) 29 (24.0) 1.8 (0.9–3.6) 0.12 1.8 (0.8–3.7) 0.14
LEPR (Gln/Gln 23 (20.2) 38 (31.4) 1.00    
LEPR (Gln/Arg) + (Arg/Arg) 91 (79.8) 83 (68.6) 1.8 (1.0–3.3) 0.05 1.8 (1.0–3.2) 0.07
Postmenopausal women (n = 95) (n = 88)     
Allele frequencies       
LEPR (Gln) 0.49 0.51     
LEPR (Arg) 0.51 0.49     
Genotype frequencies       
LEPR (Gln/Gln) 23 (24.2) 18 (20.5) 1.00    
LEPR (Gln/Arg) 47 (49.5) 53 (60.2) 0.7 (0.3–1.4) 0.33 0.7 (0.4–1.5) 0.42
LEPR (Arg/Arg) 25 (26.3) 17 (19.3) 1.2 (0.5–2.8) 0.75 1.2 (0.5–3.0) 0.62
LEPR (Gln/Gln 23 (24.2) 18 (20.5) 1.00    
LEPR (Gln/Arg) + (Arg/Arg) 72 (75.8) 70 (79.5) 0.8 (0.4–1.6) 0.54 0.9 (0.4–1.8) 0.68
  1. *Adjusted for age and waist/hip ratio (WHR)