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Table 2 Frequency of COX-2 overexpression in colorectal tumors according to tumor location

From: Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma

Tumor type Total COX-2 negative COX-2 weak (1+) overexpression COX-2 strong (2+) overexpression COX-2 any (1+, 2+) overexpression
Proximal*      
Hyperplastic polyp (HP) 5 5 (100%) 0 0 0
Sessile serrated polyp/adenoma (SSA) 2 2 (100%) 0 0 0
Mixed polyp with SSA and adenoma (MP) 1 1 (100%) 0 0 0
Traditional serrated adenoma 8 4 (50%) 3 (38%) 1 (13%) 4 (50%)
Tubular adenoma (TA) 120 53 (44%) 47 (39%) 20 (17%) 67 (56%)
Tubulovillous adenoma (TVA) 32 11 (34%) 9 (28%) 12 (38%) 21 (66%)
Villous adenoma (VA) 3 1 (33%) 1 (33%) 1 (33%) 2 (67%)
Adenoma with intramucosal carcinoma 7 3 (43%) 1 (14%) 3 (43%) 4 (57%)
Adenocarcinoma with serration 34 6 (18%) 7 (21%) 21 (62%) 28 (82%)
Adenocarcinoma without serration 31 8 (26%) 7 (23%) 16 (52%) 23 (74%)
Distal*      
Hyperplastic polyp (HP) 17 14 (82%) 2 (12%) 1 (5.9%) 3 (28%)
Sessile serrated polyp/adenoma (SSA) 4 2 (50%) 2 (50%) 0 2 (50%)
Mixed polyp with SSA and adenoma (MP) 3 2 (67%) 1 (33%) 0 1 (33%)
Traditional serrated adenoma 19 4 (21%) 11 (58%) 4 (21%) 15 (79%)
Tubular adenoma (TA) 192 76 (40%) 57 (30%) 59 (31%) 116 (60%)
Tubulovillous adenoma (TVA) 65 35 (54%) 16 (25%) 14 (22%) 30 (46%)
Villous adenoma (VA) 9 4 (44%) 3 (33%) 2 (22%) 5 (56%)
Adenoma with intramucosal carcinoma 12 2 (17%) 5 (42%) 5 (42%) 10 (83%)
Adenocarcinoma with serration 34 3 (8.8%) 4 (12%) 27 (79%) 31 (91%)
Adenocarcinoma without serration 42 4 (9.5%) 9 (21%) 29 (69%) 38 (90%)
  1. * Proximal tumors were located from cecum to transverse colon, and distal tumors were located from splenic flexure to rectum.