Table 2 Frequency of COX-2 overexpression in colorectal tumors according to tumor location
Tumor type | Total | COX-2 negative | COX-2 weak (1+) overexpression | COX-2 strong (2+) overexpression | COX-2 any (1+, 2+) overexpression |
|---|---|---|---|---|---|
Proximal* | Â | Â | Â | Â | Â |
Hyperplastic polyp (HP) | 5 | 5 (100%) | 0 | 0 | 0 |
Sessile serrated polyp/adenoma (SSA) | 2 | 2 (100%) | 0 | 0 | 0 |
Mixed polyp with SSA and adenoma (MP) | 1 | 1 (100%) | 0 | 0 | 0 |
Traditional serrated adenoma | 8 | 4 (50%) | 3 (38%) | 1 (13%) | 4 (50%) |
Tubular adenoma (TA) | 120 | 53 (44%) | 47 (39%) | 20 (17%) | 67 (56%) |
Tubulovillous adenoma (TVA) | 32 | 11 (34%) | 9 (28%) | 12 (38%) | 21 (66%) |
Villous adenoma (VA) | 3 | 1 (33%) | 1 (33%) | 1 (33%) | 2 (67%) |
Adenoma with intramucosal carcinoma | 7 | 3 (43%) | 1 (14%) | 3 (43%) | 4 (57%) |
Adenocarcinoma with serration | 34 | 6 (18%) | 7 (21%) | 21 (62%) | 28 (82%) |
Adenocarcinoma without serration | 31 | 8 (26%) | 7 (23%) | 16 (52%) | 23 (74%) |
Distal* | Â | Â | Â | Â | Â |
Hyperplastic polyp (HP) | 17 | 14 (82%) | 2 (12%) | 1 (5.9%) | 3 (28%) |
Sessile serrated polyp/adenoma (SSA) | 4 | 2 (50%) | 2 (50%) | 0 | 2 (50%) |
Mixed polyp with SSA and adenoma (MP) | 3 | 2 (67%) | 1 (33%) | 0 | 1 (33%) |
Traditional serrated adenoma | 19 | 4 (21%) | 11 (58%) | 4 (21%) | 15 (79%) |
Tubular adenoma (TA) | 192 | 76 (40%) | 57 (30%) | 59 (31%) | 116 (60%) |
Tubulovillous adenoma (TVA) | 65 | 35 (54%) | 16 (25%) | 14 (22%) | 30 (46%) |
Villous adenoma (VA) | 9 | 4 (44%) | 3 (33%) | 2 (22%) | 5 (56%) |
Adenoma with intramucosal carcinoma | 12 | 2 (17%) | 5 (42%) | 5 (42%) | 10 (83%) |
Adenocarcinoma with serration | 34 | 3 (8.8%) | 4 (12%) | 27 (79%) | 31 (91%) |
Adenocarcinoma without serration | 42 | 4 (9.5%) | 9 (21%) | 29 (69%) | 38 (90%) |