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Table 1 Frequency of COX-2 overexpression in colorectal tumors

From: Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma

Tumor type Total COX-2 negative COX-2 weak (1+) overexpression COX-2 strong (2+) overexpression COX-2 any (1+, 2+) overexpression
Hyperplastic polyp (HP) 24 21 (88%) 2 (8.3%) 1 (4.2%) 3 (13%)
Sessile serrated polyp/adenoma (SSA) 7 5 (71%) 2 (29%) 0 2 (29%)
Mixed polyp with SSA and adenoma (MP) 5 4 (80%) 1 (20%) 0 1 (20%)
Total HP, SSA and MP 36 30 (83%) 5 (14%) 1 (2.8%) 6 (17%)
Traditional serrated adenoma 27 8 (30%) 14 (52%) 5 (19%) 19 (70%)
Tubular adenoma (TA) 393 154 (39%) 132 (34%) 107 (27%) 239 (61%)
Tubulovillous adenoma (TVA) 109 49 (45%) 27 (25%) 33 (30%) 60 (55%)
Villous adenoma (VA) 13 5 (38%) 5 (38%) 3 (23%) 8 (62%)
Total non-serrated adenomas (TA, TVA, and VA) 515 208 (40%) 164 (32%) 143 (28%) 307 (60%)
Adenoma with intramucosal carcinoma 33 8 (24%) 11 (33%) 14 (42%) 25 (76%)
Adenocarcinoma with serration 96 13 (14%) 18 (19%) 65 (68%) 83 (86%)
Adenocarcinoma without serration 111 18 (16%) 23 (21%) 70 (63%) 93 (84%)
Total adenocarcinomas 207 31 (15%) 41 (20%) 135 (65%) 176 (85%)