Table 3 Replications of genotypic combinations analyses on stratifications of the patients and controls groups determined according to geographical origin and/or age.
|  | Individuals originating from Vendée | Individuals ≤ 67 years | Individuals from Vendée ≤ 67 years | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Genotypic combinations patterns | Controls (n = 189) | Cases (n = 420) | OR (95% CI) | p* | Controls (n = 768) | Cases (n = 529) | OR (95% CI) | p* | Controls (n = 134) | Cases (n = 232) | OR (95% CI) | p* |
Reference pattern | 14 | 29 | 1.00 | Â | 65 | 31 | 1.00 | Â | 12 | 16 | 1.00 | Â |
Mixed patterns | 171 | 359 | 0.92 (0.47–1.83) |  | 676 | 460 | 1.42 (0.91–2.21) |  | 120 | 195 | 1.15 (0.52–2.56) |  |
Predisposing patterns | 4 | 32 | 3.80 (1.10–13.19) | 0.011 | 27 | 38 | 3.00 (1.56–5.77) | 0.003 | 2 | 21 | 7.22 (1.38–37.80) | 0.009 |
Reference and mixed patterns | 185 | 388 | 1.00 | Â | 741 | 491 | 1.00 | Â | 132 | 211 | 1.00 | Â |
Predisposing patterns | 4 | 32 | 4.14 (1.42–12.08) | 0.002 | 27 | 38 | 2.17 (1.31–3.61) | 0.003 | 2 | 21 | 6.36 (1.44–28.09) | 0.002 |