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Table 3 Replications of genotypic combinations analyses on stratifications of the patients and controls groups determined according to geographical origin and/or age.

From: Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study

  Individuals originating from Vendée Individuals ≤ 67 years Individuals from Vendée ≤ 67 years
Genotypic combinations patterns Controls (n = 189) Cases (n = 420) OR (95% CI) p* Controls (n = 768) Cases (n = 529) OR (95% CI) p* Controls (n = 134) Cases (n = 232) OR (95% CI) p*
Reference pattern 14 29 1.00   65 31 1.00   12 16 1.00  
Mixed patterns 171 359 0.92 (0.47–1.83)   676 460 1.42 (0.91–2.21)   120 195 1.15 (0.52–2.56)  
Predisposing patterns 4 32 3.80 (1.10–13.19) 0.011 27 38 3.00 (1.56–5.77) 0.003 2 21 7.22 (1.38–37.80) 0.009
Reference and mixed patterns 185 388 1.00   741 491 1.00   132 211 1.00  
Predisposing patterns 4 32 4.14 (1.42–12.08) 0.002 27 38 2.17 (1.31–3.61) 0.003 2 21 6.36 (1.44–28.09) 0.002
  1. OR calculations were all adjusted by age and sex.