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Table 4 Distribution of ESR1 four-locus haplotype frequencies as estimated through EM algorithms among endometrial cancer cases and population controls

From: Estrogen receptor alpha gene polymorphism and endometrial cancer risk – a case-control study

Locus Proportion estimated to carry haplotype
rs2234693 rs9340799 rs4986934 rs1801132 Controls (n = 1560) All cases
(n = 694)
Endometroid cases
(n = 647)
T A C C 0.371 0.404 0.406
C G C C 0.288 0.255 0.252
C A C C 0.114 0.118 0.118
T A C G 0.123 0.137 0.135
C G C G 0.055 0.045 0.046
T A T G 0.028 0.025 0.027
Proportion accounted for by the most common haplotypes: 0.979 0.984 0.984