Estrogen receptor alpha gene polymorphism and endometrial cancer risk – a case-control study

BMC Cancer

Table 3 Odds ratios (OR) for endometrial cancer and 95% confidence intervals (CI)

			Marker	rs2234670	rs2234693	rs9340799	rs4986934	rs1801132
Genotype	00^a	Case/controls		232/441	211/382	324/573	617/1276	406/834
		OR (CI)		1 (ref)	1 (ref)	1 (ref)	1 (ref)	1 (ref)
	01^a	Case/controls		307/618	336/670	280/632	44/89	226/468
		OR (CI)	Univariate^b	0.95 (0.75–1.19)	0.88 (0.70–1.11)	0.79 (0.64–0.98)	1.02 (0.68–1.54)	1.02 (0.82–1.26)
			Multivariate^c	0.92 (0.72–1.16)	0.86 (0.68–1.10)	0.75 (0.60–0.93)	1.03 (0.67–1.58)	1.00 (0.80–1.26)
	11^a	Case/controls		123/309	115/316	58/163	1/3	30/66
		OR (CI)	Univariate^b	0.72 (0.54–0.97)	0.65 (0.48–0.87)	0.59 (0.41–0.85)	0.94 (0.09–9.40)	0.94 (0.58–1.51)
			Multivariate^c	0.73 (0.54–0.99)	0.65 (0.48–0.89)	0.53 (0.37–0.77)	1.02 (0.09–11.61)	0.95 (0.58–1.57)

Univariate results include individuals with complete information about the covariates used in the multivariate analysis.
^a The genotypes are rs2234670: 00 = ≤ 14/≤ 14, 01 = ≤ 14/> 14, 11 => 14/> 14; rs2234693: 00 = T/T, 01 = T/C, 11 = C/C; rs9340799: 00 = A/A, 01 = A/G, 11 = G/G; rs4986934: 00 = C/C, 01 = C/T, 11 = T/T; rs1801132: 00 = C/C, 01 = C/G, 11 = G/G. ^b Long-term users of menopausal hormones and diabetics were over-sampled, thus logistic regression models are conditioned for age- and sampling category, which means that only those with complete information about hormone use and diabetes mellitus were included. ^c Multivariate models are adjusted for parity (continuous), BMI (continuous), smoking (ever, never) and use of oral contraceptives (ever, never)

ISSN: 1471-2407