Estrogen receptor alpha gene polymorphism and endometrial cancer risk – a case-control study

BMC Cancer

Table 2 Distribution of endometrial cancer risk factors among participating endometrial cancer cases and population controls

Co-variate	Cases/controls	Cases	Controls
	N	Mean (SD)		P value
Age	702/1563	64.1 (6.80)	63.4 (7.03)	0.0001
Age at menarche	653/1427	13.5 (1.37)	13.5 (1.42)	0.14
Age at last birth	604/1405	29.4 (5.08)	30.4 (5.34)	0.0002
Age at menopause	614/1503	51.0 (4.06)	50.1 (3.91)	<0.0001
Recent BMI	701/1546	27.4 (5.31)	25.5 (4.27)	<0.0001
		Percent
Nulliparous	158/97	14	10
1 childbirth	289/146	21	18	0.008
2+ childbirths	1116/459	65	71
Family history^a	667/1397	10	5	<0.0001
Diabetes Mellitus, self-reported^b	702/1441	10	8	0.17
Ever use of oral contraceptives	699/1550	24	36	<0.0001
Ever use of menopausal hormones^b	690/1541	28	28	0.97
Smoking^c	702/1563	35	43	0.0004

^a Family history is defined as having a mother or a sister with endometrial cancer. ^bWomen with self-reported diabetes mellitus and those who had used menopausal hormones containing medium potency estrogens were over-sampled into the study and thus the proportions do not reflect known case-control differences ^c Smoking is defined as a participant having smoked at least 100 cigarettes during her lifetime or having smoked regularly for at least one year

ISSN: 1471-2407