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Table 5 Univariate Cox Regression Analysis of Factors Associated with Distant Disease-free Survival in the Triple-Negative Tumors

From: Frequently increased epidermal growth factor receptor (EGFR) copy numbers and decreased BRCA1 mRNA expression in Japanese triple-negative breast cancers

Variables P value Relative Risk of recurrence (95% CI)
Size   
   ≤2 cm   1.0 (reference)
   >2 cm 0.92 1.26 (0.44 to 3.65)
Nodal status   
   Negative   1.0 (reference)
   Positive 0.02 2.60 (1.14 to 6.96)
Grade   
   1   1.0 (reference)
   2, 3 0.22 2.46 (0.68 to 10.39)
TP53 expression   
   Negative   1.0 (reference)
   Positive 0.61 1.12 (0.72 to 1.77)
Ki67 expression   
   Low   1.0 (reference)
   High 0.55 0.88 (1.59 to 1.34)
EGFR IHC   
   Negative   1.0 (reference)
   Positive 0.88 1.07 (0.48 to 2.36)
EGFR gene copy number   
   <3   1.0 (reference)
   ≥3 0.2 0.27 (0.03 to 2.05)
Cytokeratins   
   Negative   1.0 (reference)
   Positive 0.42 0.72 (0.33 to 1.68)
Basal like type   
   +   1.0 (reference)
   - 0.67 0.79 (0.34 to 1.80)
  1. IHC, immunohistochemistry