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Table 2 Associations between leptin and ObR in HER2-positive and HER2-negative breast cancer

From: Leptin/HER2 crosstalk in breast cancer: in vitro study and preliminary in vivoanalysis

   ObR + ObR - p-value
   N % N %  
All tumors Leptin + 46 78.0 1 1.7 < 0.001
  Leptin - 3 5.1 9 15.3  
   N % N %  
HER2 Leptin + 23 74.2 0 0.0 < 0.001
positive Leptin - 1 3.2 7 22.6  
HER2 Leptin + 23 82.1 1 3.6 0.045
negative Leptin - 2 7.1 2 7.1  
  1. The expression of leptin and ObR was assessed by IHC, as described in Materials and Methods. The percentage (%) and actual number (N) of tumors expressing combinations of leptin and ObR is given for all tumors as well as in HER2-positive and -negative subgroups. Associations between leptin and ObR in were evaluated using Fisher's exact test for count data.