Skip to main content

Table 2 Clinicopathologic parameters and the expression of VEGF as predictors of response to neoadjuvant chemotherapy in patients with bulky cervical carcinoma

From: Prognostic significance of VEGF expression in patients with bulky cervical carcinoma undergoing neoadjuvant chemotherapy

   

Pathologic responder

Nonresponder

  

Characteristics

No. of patients

RR

CR (n = 4)

OPR a (n = 4)

(n = 21)

P b

P c

Age, years

     

0.16

 

   Median

  

58

47

46

  

   Range

  

38 – 60

34 – 60

33 – 70

  

Cervical tumor size (cm)

     

0.07

0.22

   Median

  

3.8

3.5

5.0

  

   Range

  

3.2 – 6.0

3.0 – 5.6

3.7 – 7.1

  

Clinical node involvement

     

0.98

0.22

   Yes

11

27.3%

2

1

8

  

   No

18

27.8%

2

3

13

  

Stage

     

0.67

0.54

   IB2

20

30.0%

2

4

14

  

   IIA

9

22.2%

2

0

7

  

SCC Ag level

     

0.47

0.36

   ≥5 ng/ml

14

21.4%

1

2

11

  

   < 5 ng/ml

15

33.3%

3

2

10

  

VEGF expression

     

0.009

0.032

   Negative

14

50.0%

3

4

7

  

   Positive

15

6.7%

1

0

14

  
  1. aResidual tumor but only with less than 3 mm stromal invasion
  2. bRank sum test or Chi-square test/Fisher's exact test
  3. cLogistic regression analysis with stage, tumor size, SCC-Ag level, and lymph node involvement as a covariate.
  4. RR, pathologic response rate; CR, complete response; OPR, optimal pathologic response
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us