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Table 6 Univariate and multivariate analyses according to microinvasion

From: Identification of biomarkers in ductal carcinoma in situ of the breast with microinvasion

  Univariate analysis Multivariate analysis
  Odds ratio 95% CI P-value Odds ratio 95% CI P-value
Necrosis (present vs. absent) 5.56 1.84–20.91 0.0017 5.19 1.45–22.7 0.017
Apoptotic index (1000 of positive cells vs. < 1/1000) 0.40 0.14–1.04 0.061 0.82 0.24–2.75 0.74
Ki-67 index (20% of positive cells vs. < 20%) 0.44 0.15–1.18 0.10 0.89 0.24–3.24 0.86
Bcl-2 (positive vs. negative) 2.57 0.93–7.95 0.071 3.49 1.04–13.3 0.051
Bax (positive vs. negative) 10.92 2.02–203.9 0.0028 5.21 0.70–111.1 0.16
Survivin (positive vs. negative) 4.76 1.57–17.9 0.0048 3.98 1.11–17.2 0.044
  1. CI, confidence interval