Table 3 Cancer cohort mutations detected

1

*

r

*

16S rRNA

-

*

*

r

16S rRNA

-

g

r

g

ND1

Ile>Val

t

y

t

ND1

Pro>Pro

*

r

*

ND1

Lys>Lys

g

r

g

ND2

Gln>Gln

a

r

a

tRNA^Cys

T arm

2

*

y

n/a

ND1

Pro>Pro

a

r

n/a

ND2

Met>Met

*

r

n/a

ND2

Gln>Gln

3

*

g

*

D-Loop

-

*

g

*

D-Loop

-

4

*

y

*

ND3

Leu(2)>Leu(1)

*

y

*

ND5

Leu₂>Pro

5

*

r

*

tRNA^Arg

anticodon arm

*

y

*

ND4

Phe>Phe

*

r

*

ND4

Met>Met

6

*

*

y

ATPase 6

Met>Thr

7

-

-

-

-

-

-

9

c

c

y

COI

Asp>Asp

*

y

*

ND4

Ser(1)>Pro

1

*

r

n/a

tRNASer

-

2

*

y

*

ND5

Ser(2)>Ser(2)

3

*

y

*

12S rRNA

-

4

*

n/a

y

ND2

Trp>Arg

*

n/a

y

COI

Leu(2)>Phe

*

n/a

r

ND4L

Ala>Thr

*

n/a

y

ND5

Ile>Ile

1

*

r

*

12S rRNA

-

*

y

*

16S rRNA

-

*

y

*

tRNAHis

acceptor arm

2

*

r

n/a

16S rRNA

-

*

r

n/a

ND1

Ala>Thr

3

*

y

*

ND5

Ser(1)>Ser(2)

4

*

r

*

12S rRNA

-

*

y

*

ND4

Leu(1)>Pro

5

*

y

n/a

tRNAHis

D arm

6

*

r

*

12S rRNA

-

*

r

*

tRNALeu

D arm

t

t

*

CytB

Ile>Thr

7

-

-

n/a

-

-

-

8

*

*

g

COI

Val>Val

9

*

y

*

CytB

Phe>Phe

10

*

*

y

ND5

Ile>Ile

11

-

-

-

-

-

-

12

*

*

y

ND5

Ile>Ile

13

*

y

*

CO I

Thr>Thr

14

*

a

*

D-Loop

-