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Table 2 Association of MDM2 SNP309 genotype and clinicopathological characteristics.

From: MDM2 SNP309 is associated with high grade node positive breast tumours and is in linkage disequilibrium with a novel MDM2 intron 1 polymorphism

 

309 SNP Genotype

Parameter category n (%)

   

OR (95% CI)

p

All patients (n = 299)

T/T

118 (39.5)

     
 

T/G

141 (47.2)

     
 

G/G

40 (13.4)

     

Menopausal status

(n = 299)

 

Pre

(n = 70)

Post

(n = 229)

    
 

T/T

32 (45.7)

86 (37.6)

  

0.71 (0.42 – 1.23)

0.22

 

T/G

28 (40.0)

113 (49.3)

  

1.46 (0.85 – 2.52)

0.17

 

G/G

10 (14.3)

30 (13.1)

  

0.91 (0.42 – 1.96)

0.78

ER status

(n = 299)

 

Positive

(n = 226)

Negative

(n = 71)

    
 

T/T

91 (40.3)

28 (39.4)

  

1.11 (0.643 – 1.94)

0.38

 

T/G

108 (47.8)

31 (43.7)

  

1.12 (0.65 – 1.93)

0.67

 

G/G

27 (11.9)

12 (16.9)

  

0.65 (0.31 – 1.35)

0.24

Tumour Grade

(n = 298)

 

DCIS

(n = 20)

1

(n = 47)

2

(n = 107)

3

(n = 124)

  
 

T/T

5 (25.0)

18 (38.3)

42 (39.2)

53 (42.7)

1.21 (0.93 – 1.56)

0.15

 

T/G

15 (75.0)

25 (53.2)

53 (49.5)

48 (38.7)

0.68 (0.53 – 0.88)

0.003

 

G/G

0

4 (8.5)

12 (11.2)

23 (18.5)

1.64 (1.06 – 2.53)

0.025

Nodal status

(n = 298)

 

Positive

(n = 128)

Negative

(n = 170)

    
 

T/T

50 (39.1)

67 (39.4)

  

0.98 (0.62 – 1.58)

0.95

 

T/G

53 (41.4)

88 (51.8)

  

0.66 (0.41 – 1.05)

0.07

 

G/G

25 (19.5)

15 (8.8)

  

2.51 (1.26 – 4.98)

0.009

NPI

(n = 297)

 

DCIS

(n = 20)

Good

(n = 72)

Moderate

(n = 123)

Poor

(n = 82)

  
 

T/T

5 (25.0)

30 (41.7)

47 (38.2)

35 (42.7)

1.00 (0.85 – 1.19)

0.95

 

T/G

15 (75.0)

37 (51.4)

59 (48.0)

30 (36.6)

0.87 (0.73 – 1.03)

0.11

 

G/G

0

5 (6.9)

17 (13.8)

17 (20.7)

1.30 (1.02 – 1.65)

0.03

HER-2 status

(n = 196)

 

Positive

(n = 47)

Negative

(n = 149)

    
 

T/T

18 (38.3)

57 (38.3)

  

1.00 (0.51 – 1.97)

1.00

 

T/G

19 (40.4)

73 (49.0)

  

0.71 (0.36 – 1.37)

0.30

 

G/G

10 (21.3)

19 (12.8)

  

1.85 (0.79 – 4.31)

0.16

PgR Status

(n = 294)

 

Positive

(n = 181)

Negative

(n = 113)

    
 

T/T

68 (37.6)

48 (42.5)

  

0.82 (0.49 – 1.36)

0.40

 

T/G

90 (49.7)

49 (43.4)

  

1.29 (0.78 – 2.13)

0.29

 

G/G

23 (12.7)

16 (14.1)

  

0.88 (0.42 – 1.88)

0.72

  1. Association of MDM2 SNP309 genotype and clinicopathological characteristics. Each genotype was compared to all the other samples. OR = Odds ratio, CI = Confidence interval.
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