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Table 2 Association of MDM2 SNP309 genotype and clinicopathological characteristics.

From: MDM2 SNP309 is associated with high grade node positive breast tumours and is in linkage disequilibrium with a novel MDM2 intron 1 polymorphism

  309 SNP Genotype Parameter category n (%)     OR (95% CI) p
All patients (n = 299) T/T 118 (39.5)      
  T/G 141 (47.2)      
  G/G 40 (13.4)      
Menopausal status
(n = 299)
  Pre
(n = 70)
Post
(n = 229)
    
  T/T 32 (45.7) 86 (37.6)    0.71 (0.42 – 1.23) 0.22
  T/G 28 (40.0) 113 (49.3)    1.46 (0.85 – 2.52) 0.17
  G/G 10 (14.3) 30 (13.1)    0.91 (0.42 – 1.96) 0.78
ER status
(n = 299)
  Positive
(n = 226)
Negative
(n = 71)
    
  T/T 91 (40.3) 28 (39.4)    1.11 (0.643 – 1.94) 0.38
  T/G 108 (47.8) 31 (43.7)    1.12 (0.65 – 1.93) 0.67
  G/G 27 (11.9) 12 (16.9)    0.65 (0.31 – 1.35) 0.24
Tumour Grade
(n = 298)
  DCIS
(n = 20)
1
(n = 47)
2
(n = 107)
3
(n = 124)
  
  T/T 5 (25.0) 18 (38.3) 42 (39.2) 53 (42.7) 1.21 (0.93 – 1.56) 0.15
  T/G 15 (75.0) 25 (53.2) 53 (49.5) 48 (38.7) 0.68 (0.53 – 0.88) 0.003
  G/G 0 4 (8.5) 12 (11.2) 23 (18.5) 1.64 (1.06 – 2.53) 0.025
Nodal status
(n = 298)
  Positive
(n = 128)
Negative
(n = 170)
    
  T/T 50 (39.1) 67 (39.4)    0.98 (0.62 – 1.58) 0.95
  T/G 53 (41.4) 88 (51.8)    0.66 (0.41 – 1.05) 0.07
  G/G 25 (19.5) 15 (8.8)    2.51 (1.26 – 4.98) 0.009
NPI
(n = 297)
  DCIS
(n = 20)
Good
(n = 72)
Moderate
(n = 123)
Poor
(n = 82)
  
  T/T 5 (25.0) 30 (41.7) 47 (38.2) 35 (42.7) 1.00 (0.85 – 1.19) 0.95
  T/G 15 (75.0) 37 (51.4) 59 (48.0) 30 (36.6) 0.87 (0.73 – 1.03) 0.11
  G/G 0 5 (6.9) 17 (13.8) 17 (20.7) 1.30 (1.02 – 1.65) 0.03
HER-2 status
(n = 196)
  Positive
(n = 47)
Negative
(n = 149)
    
  T/T 18 (38.3) 57 (38.3)    1.00 (0.51 – 1.97) 1.00
  T/G 19 (40.4) 73 (49.0)    0.71 (0.36 – 1.37) 0.30
  G/G 10 (21.3) 19 (12.8)    1.85 (0.79 – 4.31) 0.16
PgR Status
(n = 294)
  Positive
(n = 181)
Negative
(n = 113)
    
  T/T 68 (37.6) 48 (42.5)    0.82 (0.49 – 1.36) 0.40
  T/G 90 (49.7) 49 (43.4)    1.29 (0.78 – 2.13) 0.29
  G/G 23 (12.7) 16 (14.1)    0.88 (0.42 – 1.88) 0.72
  1. Association of MDM2 SNP309 genotype and clinicopathological characteristics. Each genotype was compared to all the other samples. OR = Odds ratio, CI = Confidence interval.