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Table 3 All clinicopathological factors influencing clinical endpoints in the TP53-negative and TP53-positive group.

From: TP53 status and taxane-platinum versus platinum-based therapy in ovarian cancer patients: A non-randomized retrospective study

  TP53(-) group, N = 186 TP53(+) group, N = 266
  OR or HR [95% C.I.] P value OR or HR [95% C.I.] P value
Complete remission (CR)     
PC/PAC -   1.0  
TP - >0.1 3.28 [1.22,8.83] 0.018
Age ≤53 yrs 1.0   -  
Age >53 0.53 [0.27,1.02] 0.057 -  
Residual tumor 0 1.0   1.0  
Residual tumor ≤2 cm 0.15 [0.01,0.54] 0.004 -  
Residual tumor >2 cm 0.06 [0.02,0.24] 0.000 0.16 [0.094,0.29] 0.000
other histological types 1.0   -  
endometrioid, CCC 0.28 [0.08, 0.96] 0.044 -  
FIGO IIB-IIIC -   1.0  
FIGO IV -   0.35 [0.15,0.81] 0.014
Platinum sensitivity (PS)     
PC/PAC -   1.0  
TP - >0.1 1.96 [1.14, 3.35] 0.014
Residual tumor 0 1.0   1.0  
Residual tumor ≤2 cm 0.15 [0.054, 0.45] 0.001 -  
Residual tumor >2 cm 0.08 [0.028, 0.23] 0.000 0.21 [0.126, 0.36] 0.000
FIGO IIB–IIIC -   1.0  
FIGO IV -   0.38 [0.158, 0.91] 0.031
Platinum high sensitivity (PHS)     
PC/PAC 1.0   1.0  
TP 0.006 [0.001, 0.29] 0.010 >10 [1.14, +] 0.038
FIGO IIB/C 1.0   1.0  
FIGO IIIA/B 0.06 [0.004, 0.68] 0.024 -  
FIGO IIIC 0.01 [0.001, 0.18] 0.001 0.47 [0.21,1.07] 0.075
FIGO IV 0.008 [0.000, 0.20] 0.003 0.13 [0.02,0.72] 0.021
Residual tumor 0 -   1.0  
Residual tumor ≤2 cm - 0.012 0.41 [0.18,0.96] 0.04
Residual tumor >2 cm -   0.09 [0.02, 0.37] 0.001
Disease free survival (DFS)     
PC/PAC versus TP   >0.1   >0.1
FIGO IIB-IIIB 1.0   1.0  
FIGO IIIC 2.17 [1.31,3.60]   -  
FIGO IV 3.04 [1.22,7.62] 0.003 2.20 [1.17,4.16] 0.014
Grade 3,4 - 0.017 1.0  
Grade 2 -   0.34 [0.16,0.72] 0.005
Residual tumor 0 -   1.0  
Residual tumor ≤2 cm -   1.68 [1.07,2.64] 0.023
Residual tumor >2 cm -   2.14 [1.34,3.39] 0.001
Overall survival (OS)     
PC/PAC -   1.0  
TP - >0.1 0.15 [0.04, 0.60] 0.007
Age 53 1.0   1.0  
Age >53 1.5 [0.95, 2.25] 0.085 1.66 [1.14, 2.41] 0.008
Residual tumor 0 1.0   1.0  
Residual tumor ≤2 cm 2.48 [1.42,4.32] 0.001 1.72 [1.07,2.75] 0.023
Residual tumor >2 cm 3.13 [1.83,5.34] 0.000 2.43 [1.52,3.9] 0.000
other histological types 1.0   -  
endometrioid, CCC 1.76 [1.09,2.85] 0.02 -  
FIGO IIB/C -   1.0  
FIGO IIIA/B -   2.1 [0.92,4.76] 0.078
FIGO IIIC -   2.58 [1.13,5.87] 0.024
FIGO IV -   5.04 [2.06,12.27] 0.000