Table 3 All clinicopathological factors influencing clinical endpoints in the TP53-negative and TP53-positive group.
| Â | TP53(-) group, N = 186 | TP53(+) group, N = 266 | ||
|---|---|---|---|---|
| Â | OR or HR [95% C.I.] | P value | OR or HR [95% C.I.] | P value |
Complete remission (CR) | Â | Â | Â | Â |
PC/PAC | - | Â | 1.0 | Â |
TP | - | >0.1 | 3.28 [1.22,8.83] | 0.018 |
Age ≤53 yrs | 1.0 |  | - |  |
Age >53 | 0.53 [0.27,1.02] | 0.057 | - | Â |
Residual tumor 0 | 1.0 | Â | 1.0 | Â |
Residual tumor ≤2 cm | 0.15 [0.01,0.54] | 0.004 | - |  |
Residual tumor >2 cm | 0.06 [0.02,0.24] | 0.000 | 0.16 [0.094,0.29] | 0.000 |
other histological types | 1.0 | Â | - | Â |
endometrioid, CCC | 0.28 [0.08, 0.96] | 0.044 | - | Â |
FIGO IIB-IIIC | - | Â | 1.0 | Â |
FIGO IV | - | Â | 0.35 [0.15,0.81] | 0.014 |
Platinum sensitivity (PS) | Â | Â | Â | Â |
PC/PAC | - | Â | 1.0 | Â |
TP | - | >0.1 | 1.96 [1.14, 3.35] | 0.014 |
Residual tumor 0 | 1.0 | Â | 1.0 | Â |
Residual tumor ≤2 cm | 0.15 [0.054, 0.45] | 0.001 | - |  |
Residual tumor >2 cm | 0.08 [0.028, 0.23] | 0.000 | 0.21 [0.126, 0.36] | 0.000 |
FIGO IIB–IIIC | - |  | 1.0 |  |
FIGO IV | - | Â | 0.38 [0.158, 0.91] | 0.031 |
Platinum high sensitivity (PHS) | Â | Â | Â | Â |
PC/PAC | 1.0 | Â | 1.0 | Â |
TP | 0.006 [0.001, 0.29] | 0.010 | >10 [1.14, +] | 0.038 |
FIGO IIB/C | 1.0 | Â | 1.0 | Â |
FIGO IIIA/B | 0.06 [0.004, 0.68] | 0.024 | - | Â |
FIGO IIIC | 0.01 [0.001, 0.18] | 0.001 | 0.47 [0.21,1.07] | 0.075 |
FIGO IV | 0.008 [0.000, 0.20] | 0.003 | 0.13 [0.02,0.72] | 0.021 |
Residual tumor 0 | - | Â | 1.0 | Â |
Residual tumor ≤2 cm | - | 0.012 | 0.41 [0.18,0.96] | 0.04 |
Residual tumor >2 cm | - | Â | 0.09 [0.02, 0.37] | 0.001 |
Disease free survival (DFS) | Â | Â | Â | Â |
PC/PAC versus TP | Â | >0.1 | Â | >0.1 |
FIGO IIB-IIIB | 1.0 | Â | 1.0 | Â |
FIGO IIIC | 2.17 [1.31,3.60] | Â | - | Â |
FIGO IV | 3.04 [1.22,7.62] | 0.003 | 2.20 [1.17,4.16] | 0.014 |
Grade 3,4 | - | 0.017 | 1.0 | Â |
Grade 2 | - | Â | 0.34 [0.16,0.72] | 0.005 |
Residual tumor 0 | - | Â | 1.0 | Â |
Residual tumor ≤2 cm | - |  | 1.68 [1.07,2.64] | 0.023 |
Residual tumor >2 cm | - | Â | 2.14 [1.34,3.39] | 0.001 |
Overall survival (OS) | Â | Â | Â | Â |
PC/PAC | - | Â | 1.0 | Â |
TP | - | >0.1 | 0.15 [0.04, 0.60] | 0.007 |
Age 53 | 1.0 | Â | 1.0 | Â |
Age >53 | 1.5 [0.95, 2.25] | 0.085 | 1.66 [1.14, 2.41] | 0.008 |
Residual tumor 0 | 1.0 | Â | 1.0 | Â |
Residual tumor ≤2 cm | 2.48 [1.42,4.32] | 0.001 | 1.72 [1.07,2.75] | 0.023 |
Residual tumor >2 cm | 3.13 [1.83,5.34] | 0.000 | 2.43 [1.52,3.9] | 0.000 |
other histological types | 1.0 | Â | - | Â |
endometrioid, CCC | 1.76 [1.09,2.85] | 0.02 | - | Â |
FIGO IIB/C | - | Â | 1.0 | Â |
FIGO IIIA/B | - | Â | 2.1 [0.92,4.76] | 0.078 |
FIGO IIIC | - | Â | 2.58 [1.13,5.87] | 0.024 |
FIGO IV | - | Â | 5.04 [2.06,12.27] | 0.000 |