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Table 1 Potential CREB target genes.

From: Expression profile of CREB knockdown in myeloid leukemia cells

Gene Name Fold Change CREB binding CREB site Gene Name Fold Change CREB binding CREB site
DKFZP434G222 0.551725 3.883395 ht h HSPC056 0.44548 1.892546 ht h
ABCG2 0.479066 2.244422 ht h HSU79303 0.573524 1.812829 ht
ALDH2 0.5604 1.989872 none ILVBL 0.675128 1.893295 ht h
ALDH7A1 0.62012 2.051646 h KIAA0103 0.682528 2.620283 ht h
ALS2CR19 0.46208 1.788188 ht HSU79303 0.573524 1.812829 ht
ANC_2H01 0.659044 1.991467 ht h ILVBL 0.675128 1.893295 ht h
ANG 0.693535 3.287977 ht KIAA0103 0.682528 2.620283 ht h
APLP2 0.636685 1.219917 h KIAA0141 0.689536 3.479426 h
APPL 0.668234 1.391059 h KIAA0408 0.595271 3.603389 none
ARFD1 0.524897 2.336962 ht KIAA0494 0.67838 5.420821 F
BCL2L11 0.589894 3.191337 H h KLF5 0.553523 2.062499 H
BECN1 0.600243 1.151217 H h KNSL8 0.468603 7.854334 HT ft
BMX 0.315984 1.072006 none KPNA5 0.562667 2.859517 none
C20orf133 0.635849 2.420642 h LANCL1 0.647544 1.020319 none
C6orf67 0.610619 2.665053 h LOC51668 0.500097 1.062053 ht h
CA2 0.592202 1.082939 ht LOC51762 0.599397 3.307553 ht h
CALB2 0.671562 1.894443 h LYPLA3 0.664078 2.379015 HT h
CCDC2 0.533032 1.529166 none MAF 0.597194 2.383458 FT
CENPE 0.306986 3.736367 FT ht MAPKAPK5 0.699356 2.053184 FH
CGI-77 0.664435 4.334985 H ht h MDM2 0.468991 2.523732 none
CLDN18 0.566707 4.30699 ht h MGC15419 0.617252 3.032433 h
CNN1 0.670957 1.150221 F ht h MPHOSPH1 0.423771 3.535138 ht h
CREB1 0.382751 1.816762 HT H ht h MSH2 0.592302 3.203985 h
CSPG6 0.573523 3.082765 h MVD 0.632896 3.854905 ht h
CUL5 0.683117 2.073118 H ht h MYL4 0.69963 1.010099 h
DBP 0.67969 2.805267 ft ht NEFL 0.343403 2.413823 HT h
DES 0.521516 1.509794 ht h NFKBIL1 0.695019 4.072353 ht
DIS3 0.692573 3.837304 HT ht NIPSNAP1 0.679129 1.215594 h
DNCI1 0.673721 2.195167 none NOX3 0.455479 2.60292 h
DNMT3A 0.679821 1.035348 h NR4A3 0.543361 5.002146 HT H h
DSIPI 0.40458 2.546212 HT NUDT5 0.673003 2.561752 h
DUSP19 0.674195 2.225933 none NUMB 0.675667 1.014954 HT ht
EIF2S1 0.631867 1.075696 H ht h PDE6B 0.66696 2.699363 h
EIF2S2 0.644661 3.313634 ht h PEX12 0.694707 6.199684 h
ESRRBL1 0.67914 4.633352 FH h PFDN4 0.507631 2.196535 none
FBXO22 0.688756 2.206273 ht PHC1 0.672187 1.053985 HT
FECH 0.516446 1.045191 h PKD2L2 0.513894 2.249593 h
FECH 0.658471 1.045191 h PLAA 0.603854 9.235476 none
FLJ10853 0.622952 3.981514 H ht PPP1R2 0.568734 2.04019 ft
FLJ10858 0.668758 1.523113 none PRDX3 0.615229 1.847784 none
FLJ10904 0.54026 1.085341 none PSAT1 0.47554 2.492965 ht
FLJ11011 0.610253 3.387879 ht h PSMAL/GCP 0.68221 1.341117 none
FLJ11342 0.683482 2.617474 ht PTGS2 0.684401 3.057276 ht h
FLJ11712 0.62618 2.776373 ht RAB31 0.698664 1.12667 ht
FLJ13491 0.633125 3.268155 none RB1CC1 0.533475 1.390318 none
FLJ20130 0.640787 2.766588 h RFC3 0.577787 6.745001 FH ht
FLJ20331 0.681859 8.752576 H RHEB 0.682202 3.47317 HT H h
FLJ20333 0.690542 1.946262 ht h RNASE4 0.436168 2.975774 ht h
FLJ20509 0.691949 1.96435 none SARS2 0.692149 5.455469 H h
FLJ23233 0.471676 1.517415 none SBBI26 0.683312 6.75719 H
FOXD1 0.593522 5.160553 HT ht SDP35 0.502432 2.320591 h
GCAT 0.656744 2.122675 ht h SERPINI1 0.31594 3.277692 ht
GCHFR 0.676365 2.188753 ht h SHMT1 0.658252 1.127084 ht h
GFI1B 0.671179 0.999255 h SILV 0.662805 2.130617 H
GMPR 0.672975 1.149663 ht SLC11A2 0.684325 1.842417 none
GOLGA4 0.567882 2.939327 ht h SLC22A5 0.657746 1.64513 none
GPNMB 0.410992 1.004344 none SLC27A6 0.547039 1.029816 ht
GRHPR 0.68706 2.454475 H ht SLC2A4 0.507466 2.273185 ht h
H2BFS 0.591569 2.358423 ht SLC39A8 0.201136 1.004832 none
HBE1 0.639376 0.947159 h SLC4A7 0.532067 1.262531 ht
HDGFRP3 0.65013 1.208322 none SMARCA1 0.519982 1.056916 HT ht
HDGFRP3 0.668211 1.208322 none SMC2L1 0.596288 2.916083 ht h
HEXA 0.54467 2.622927 none SRI 0.671893 0.826457 ht
HIST1H1C 0.590374 1.983514 h STK16 0.680797 6.555535 H h
HIST1H2AD 0.66909 4.768013 ht h SULT1C2 0.599235 3.511947 f h
HIST1H2AI 0.542518 2.801688 H ht h SURB7 0.498245 1.598812 ht
HIST1H2AJ 0.696531 3.066865 ft ht h SYN1 0.696375 3.016534 F h
HIST1H2AL 0.602018 2.600144 FHT ht h TAF1A 0.589389 2.689618 none
HIST1H2BB 0.590821 1.782458 ht h TBC1D7 0.692755 1.281463 ht
HIST1H2BD 0.674855 3.111055 HT ht h TCTE1L 0.368312 2.475611 ht
HIST1H2BE 0.546621 2.34815 ht TFDP2 0.670657 1.016413 ht
HIST1H2BF 0.543665 1.985466 ht TGDS 0.67197 1.523411 none
HIST1H2BH 0.617917 2.04185 none THRB 0.670555 2.256453 H ht h
HIST1H2BI 0.585897 1.443622 ht TMEM14A 0.656093 1.175355 ht h
HIST1H2BJ 0.493823 5.335159 HT ht h TOM1 0.64031 3.221137 h
HIST1H2BM 0.687469 3.533372 ft ht h TXN2 0.689274 1.893339 H ht h
HIST1H2BO 0.618862 4.014214 ht h UBE2B 0.663194 3.652863 H ht h
HIST1H3B 0.556438 4.260113 ft ht VRK1 0.650583 1.000406 h
HIST1H3H 0.641946 2.647758 H ht h WASPIP 0.572355 1.01892 none
HIST1H4E 0.608257 2.458831 FT h WDHD1 0.624889 4.984045 H ht h
HIST1H4I 0.612088 2.068983 ht WWOX 0.671866 1.882778 h
HIST2H2AA 0.560962 4.032876 ht ZNF134 0.677481 2.726853 ht h
HLA-DRA 0.365141 3.086303 ht h ZNF222 0.5618 4.09755 ht h
HLXB9 0.667926 1.006593 none ZNF230 0.410725 3.76825 ht h
HS2ST1 0.694429 1.032562 ht h ZNF235 0.38371 2.959812 none
HSBP1 0.671929 1.891961 ht h     
  1. Top down-regulated genes that show significant CREB binding and changes in expression in the CREB knockdown cells. The detailed criteria for selecting these genes are described in the methods section. For each grouping of genes, from left to right, column 1 shows the gene symbols, column 2 the ratio of the expression change in wild type versus knockdown, column 3 the CREB binding ratio and column 4 the presence of CREB binding motifs. The key for column 4 is as follows: F is a full CREB motif (TGACGCTA) that is conserved from human to mouse, while f is not conserved, H is a conserved CREB half motif (TGACG or CGTCA), while h is not conserved, and T is the conserved presence of a TATA motif less than 300 base pairs downstream of the CREB motif, while t is not conserved.