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Table 1 Summary of the molecular and histological features of the colorectal polyps analyzed

From: BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: Primary or secondary genetic events in colorectal carcinogenesis?

  Molecular Classification Histological classification
Sample KRAS BRAF PIK3CA CIMP MLH1 methylation Microsatellite instability Polyp type Dysplasia
1 G12D - - Negative UnMet MSS MHA Mild
2 G12D - - Negative nd MSS MHA Mild
3 G12V - - nd UnMet MSS MHA Mild
4 G12V - - Negative nd MSS HP -
5 G13D - - Negative nd MSS HP -
6 G13D - - Negative nd MSS MHA Mild
7 - V600E - Positive UnMet MSS SA Mild
8 - V600E - Positive UnMet MSS SA Mild
9 - V600E - Positive nd MSS SA Mild
10 - V600E - Negative nd MSS SA Mild
11 - V600E - nd nd MSS SA Moderate
12 - - R1023Q nd nd MSS MHA Mild
13 - - - Negative UnMet MSS MHA Mild
14 - - - Negative UnMet MSS HP -
15 - - - Negative UnMet MSS MHA Mild
16 - - - nd nd MSS MHA Mild
17 - - - nd nd MSS HP -
  1. UnMet – unmethylated; nd – not determined; MHA – Mixed hyperplastic and adenomatous; HP – Hyperplastic polyp; SA – Serrated adenoma