ITIH2 immunohistochemistry on TMA derived from normal and cancerous breast tissue. A+B: Strong cytoplasmic staining is seen in normal epithelial cells of the mammary gland. C+D: Ductal carcinoma in-situ (high grade type) with moderate focal cytoplasmic staining and normal, partially hyperplastic gland epithelium with strong cytoplasmic staining (see arrows). E-H: Invasive ductal carcinoma with either negative (E, F) or strong ITIH2 staining (G, H). Magnification: 100× (A, C, E, G), 400× (B, D, F, H).