Compound | Number of Cases (%) | Number of Controls (%) | Multivariate ORd(95% CI) |
---|
None/Infrequent Use
a
| 236 (72) | 352 (54) | 1.00 |
COX-2 Inhibitors
b
| 15 (5) | 53 (8) | 0.31 (0.16–0.57) |
OTC NSAIDs
c
| | | |
Aspirin
| 22 (7) | 88 (13) | 0.33 (0.20–0.56) |
Ibuprofen/Naproxen
| 13 (4) | 68 (11) | 0.28 (0.15–0.54) |
Acetaminophen
| 12 (3) | 22 (3) | 0.81 (0.35–1.61) |
Baby Aspirin
| 28 (9) | 69 (11) | 0.58 (0.35–1.02) |
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a No use of any NSAID or analgesic or infrequent use of no more than one pill per week for less than one year;
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b COX-2 inhibitors include celecoxib, rofecoxib, valdecoxib, and meloxicam used daily for one year or more.
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c Over the counter (OTC) NSAIDs/analgesics used at least once per week for more than one year.
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d Multivariate odds ratios are adjusted for continuous variables (body mass) and categorical variables (hypertension, family history, smoking, and alcohol intake).