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Table 2 Expression of phospho-eIF2α in normal and malignant lung specimens.

From: Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells

    Immunohistochemical Staining Index (ISI)
Histology Cellular Compartment # of Cases 0–11 > 1–3 > 3–6 > 6–9 > 9–12
Normal Lung Tissue Normal cell compartment 8 8 0 0 0 0
Non-Small Cell Carcinoma2   93      
  Tumor cell compartment   41 18 22 9 3
  Normal cell compartment   87 4 2 0 0
Small Cell Carcinoma2   4      
  Tumor cell compartment   2 0 1 1 0
  Normal cell compartment   4 0 0 0 0
Mixed Carcinoma Types2   8      
  Tumor cell compartment   5 0 2 1 0
  Normal cell compartment   8 0 0 0 0
  1. 1An ISI value of 0–1 is considered negative, while an ISI value of > 1 is considered positive, with the 4 groups (i.e., > 1–3, > 3–6, > 6–9, > 9–12) indicate an increasing level of expression intensity and rate.
  2. 2For each tissue specimen tumor cells and non-tumor cells were scored separately for percent immunohistochemical reactivity and staining intensity as described in the Methods Section. The product of the percentage and intensity scores was used to generate an immunohistochemical staining index (ISI) for each cellular component (i.e., tumor and non-tumor) of each specimen.