Table 5 Multiparametric tumor marker analysis in colorectal cancer.
Colorectal cancer | ||||
|---|---|---|---|---|
Sensitivity | Specificity | |||
Two markers | Both positive | Either positive | Both negative | Either negative |
PAI-1 + CATB | 78% | 98% | 73% | 98% |
PAI-1 + uPA | 64% | 98% | 67% | 98% |
PAI-1 + CATL | 39% | 96% | 67% | 96% |
CATB + uPA | 55% | 95% | 79% | 87% |
CATB + CATL | 41% | 84% | 75% | 94% |
CATL + uPA | 30% | 80% | 72% | 90% |
PAI-1 + CEA | 30% | 96% | 73% | 98% |
CATB + CEA | 28% | 84% | 83% | 95% |
uPA + CEA | 20% | 80% | 76% | 95% |
CATL + CEA | 20% | 52% | 75% | 94% |
PAI-1 + CA 19-9 | 18% | 96% | 77% | 98% |
CATB + CA 19-9 | 16% | 84% | 86% | 97% |
uPA + CA 19-9 | 14% | 73% | 80% | 95% |
CATL + CA 19-9 | 11% | 48% | 78% | 95% |
CEA + CA 19-9 | 16% | 32% | 86% | 97% |
Three markers | All positive | Either positive | All negative | Either negative |
PAI-1 +CEA +CA 19-9 | 16% | 96% | 71% | 98% |
CATB +CEA +CA 19-9 | 14% | 84% | 80% | 97% |
uPA +CEA +CA 19-9 | 12% | 80% | 74% | 97% |
CATL +CEA +CA 19-9 | 9% | 52% | 74% | 97% |