Survival curves stratified by cathepsin B, cathepsin L and plasminogen activator inhibitor type-1 in colorectal cancer. The association of preoperative serum cathepsin B (CATB), cathepsin L (CATL) and plasma plasminogen activator inhibitor type-1 (PAI-1) antigen levels and overall survival in patients with primary colorectal carcinoma (CRC) (n = 56). By using the median values of CATB, CATL and PAI-1 the patients were divided into two groups. High antigen levels identified patients with shorter survival and those who were at higher risk of death. Group-oriented curves for survival were calculated according to the Kaplan-Meier method. The P values are shown in the figure. A. CATB in sera of patients with CRC (CATB median as a cut-off value, 8.75 ng/ml). B. CATL in sera of patients with CRC (CATL median as a cut-off value, 1.1 ng/ml). C. PAI-1 in plasma of patients with CRC (PAI-1 median as a cut-off value, 52.45 ng/ml).