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Table 2 Patient characteristics and enzymes activities

From: Clinical implications of thymidylate synthetase, dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferase activity levels in colorectal carcinoma following radical resection and administration of adjuvant 5-FU chemotherapy

Factor

n

TS activity Tumor: Normal colon

DPDS activity Tumor: Normal colon

OPRT activity Tumor: Normal colon

Mean Age:

40

10.8 ± 8.0 2.1 ± 1.2

28.1 ± 24.0 29.9 ± 14.6

0.50 ± 0.11 0.23 ± 0.07

Age:

    

   young < 69

24

11.6 ± 8.7 2.6 ± 0.8

30.5 ± 28.9 28.6 ± 14.8

0.54 ± 0.10 0.20 ± 0.09

   Old > 70

16

10.0 ± 8.1 1.6 ± 1.8

27.2 ± 20.7 30.7 ± 12.1

0.48 ± 0.14 0.25 ± 0.05

Gender:

    

   male

23

12.1 ± 9.8 2.2 ± 1.4

25.8 ± 27.7 28.8 ± 15.8

0.54 ± 0.13 0.20 ± 0.09

   Female

17

9.9 ± 9.5 2.0 ± 1.1

32.3 ± 21.3 30.6 ± 11.2

0.49 ± 0.12 0.24 ± 0.07

Histological type

    

   Well

22

11.90 ± 5.6 2.3 ± 1.0

26.9 ± 21.8 31.8 ± 15.9

0.56 ± 0.12 0.20 ± 0.11

   Moderately

18

10.0 ± 11.8 1.9 ± 1.5

30.5 ± 25.9 27.6 ± 11.8

0.45 ± 0.14 0.23 ± 0.05

Nodal status

    

   N(-)

22

9.5 ± 10.2 2.7 ± 1.8

27.9 ± 27.8 32.0 ± 12.1

0.65 ± 0.11* 0.22 ± 0.08

   N(+)

18

12.5 ± 6.9 1.5 ± 0.8

30.0 ± 22.8 26.5 ± 17.2

0.41 ± 0.13* 0.23 ± 0.07

Tumor depth

    

   s.s.

26

10.0 ± 6.7 1.9 ± 0.9

27.5 ± 19.8 32.8 ± 11.5

0.54 ± 0.13 0.23 ± 0.08

   s.e.

14

12.1 ± 9.8 2.3 ± 1.8

29.2 ± 29.7 26.1 ± 15.3

0.48 ± 0.11 0.23 ± 0.08

Tumor size

    

   > 5.0 cm

27

9.5 ± 6.6 2.6 ± 1.0

27.7 ± 27.8 35.7 ± 19.9

0.54 ± 0.13 0.22 ± 0.07

   < 4.9 cm

13

12.5 ± 9.5 1.7 ± 1.9

30.9 ± 20.8 23.9 ± 9.9

0.48 ± 0.12 0.23 ± 0.09

  1. s.s.: histological tumor invasion of subserosa, s.e.: histological tumor invasion of serosa
  2. *P < 0.05 (p mol/min/mg-protein)
  3. Values represent mean ± SD.