Figure 4

Results of the Principal Component Analysis (PCA). Visualization of the three principal component directions corresponding to the largest variation in the pilot data after selection of the 3000 genes with the largest degree of differential expression (Kruskal-Wallis) and projection of the independent data set onto these principal components. * = individual pilot sample, + = individual independent data set sample, o = mean expression in each class in the pilot data, Δ = mean expression of the projected independent data set class; blue = stage I without recurrence; green = stage I with recurrence; red = platin-sensitive advanced stage; black = platin-resistant advanced stage. Top panel) projection of the stage I independent data set samples, Middle panel) projection of the platin-sensitive advanced stage independent data set samples, Bottom panel) projection of the platin-resistant advanced stage independent data set samples.