Antisense oligonucleotides and all-trans retinoic acid have a synergistic anti-tumor effect on oral squamous cell carcinoma

Table 1 Effect of combined treatment of As-ODN-hTR and ATRA on the growth of tumors.

FTV relative to untreated controls^a
			Combination treatment
Treated Day^b	As-ODN-hTR	ATRA	Expected^c	Observed	Ratio of expected FTV/observed FTV^d
3	0.972	0.894	0.869	0.945	0.92
7	0.848	0.883	0.749	0.841	0.891
10	0.957	0.922	0.882	0.794	1.111
14	0.99	0.9	0.89	0.844	1.055
17	0.892	0.877	0.782	0.681	1.149
21	0.753	0.879	0.662	0.531	1.246
24	0.618	0.783	0.484	0.379	1.277
28	0.53	0.684	0.363	0.302	1.202

^a FTV, fractional tumor volume, calculated as mean tumor volume experimental/mean tumor volume control.
^bDay after tumors treated with agents.
^cMean FTV of As-ODN-hTR X mean FTV of ATRA.
^dObtained by dividing the expected FTV by the observed FTV. A ratio of >1 indicates a synergistic effect, and a ratio of <1 indicates a less than additive effect.

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