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Table 2 Clinicopathological parameters in relation to ID4 promoter methylation

From: Promoter methylation-associated loss of ID4expression is a marker of tumour recurrence in human breast cancer

Variable ID4Methylation
  na Positive Negative P-valued
Total 170 117 53  
Clinicopathological parameters:     
Age at diagnosis     
   <50 years 51 34 17 0.821
   ≥ 50 years 111 76 35  
Tumour sizeb     
   pT1 62 24 44 0.247
   pT2-4 91 27 7  
Lymph node statusb     
   pN0 74 43 31 0.030
   pN1-3 62 47 15  
Histological grade     
   G1 14 10 4 0.944
   G2 79 52 27  
   G3 61 42 19  
Histological type     
   invasive ductal 129 87 42 0.940
   invasive lobular 18 12 6  
   other 12 8 4  
Oestrogen receptor status     
   negative (IRSc 0–2) 52 35 17 0.900
   positive (IRS 3–12) 101 69 32  
Progesterone receptor status     
   negative (IRS 0–2) 57 39 18 0.920
   positive (IRS 3–12) 96 65 31  
ID4 mRNA expression x-fold     
   FC<2 8 0 8 <0.001
   FC≥2 38 31 7  
  1. a Only female patients with primary, unilateral, invasive breast cancer were included. Significant P- values are marked in bold face. bAccording to TNM classification by Sobin and Wittekind [37]. c IRS = Immuno-reactive score according to Remmele and Stegner [38]. dFisher's exact test. Significant P- values are marked in bold face.