| | |
Overall frequency
|
Responder
| |
|---|
| | |
No. of Pts
|
%
|
No. of Pts
|
RR (%)
|
p-value*
|
|
Age
|
≤ 55
|
31
|
42.5
|
15
|
48.4
|
0.501
|
| |
> 55
|
42
|
57.5
|
17
|
40.5
| |
|
Performance
|
ECOG 0–1
|
60
|
82.2
|
28
|
46.7
|
0.295
|
| |
ECOG 2
|
13
|
17.8
|
4
|
30.8
| |
|
Histotype
|
Intestinal
|
47
|
67.1
|
19
|
40.4
|
0.557
|
| |
Diffuse
|
23
|
32.9
|
11
|
47.8
| |
| |
unknown
|
3
| | | | |
|
Disease status
|
Initial stage IV
|
54
|
74.0
|
27
|
50.0
|
0.107
|
| |
Relapsed
|
19
|
26.0
|
5
|
26.3
| |
|
TS in 5'UTR#
|
2R/2R, 2R/3C, 3C/3C
|
21
|
28.8
|
7
|
33.3
|
0.285
|
| |
2R/3G, 3C/3G, 3G/3G
|
51
|
69.9
|
24
|
47.1
| |
| |
unknown
|
1
|
1.4
| | | |
|
TS 6-bp deletion in 3'UTR
|
-6/-6
|
40
|
54.8
|
22
|
55.0
|
0.034
|
| |
+6/+6 or +6/-6
|
33
|
45.2
|
10
|
30.3
| |
|
GSTP1-Ile105Val (A105G)
|
A/A
|
44
|
60.3
|
22
|
50.0
|
0.191
|
| |
A/G or G/G
|
29
|
39.7
|
10
|
34.5
| |
|
ERCC-Asn118Asn
|
C/C
|
40
|
54.8
|
17
|
42.5
|
0.800
|
| |
C/T or T/T
|
33
|
45.2
|
15
|
57.5
| |
|
ERCC-C8092A
|
C/C
|
44
|
60.3
|
18
|
40.9
|
0.535
|
| |
C/A or A/A
|
29
|
39.7
|
14
|
48.3
| |
|
XPD- Arg156Arg
|
C/C
|
23
|
31.5
|
6
|
26.1
|
0.038
|
| |
C/A or A/A
|
50
|
54.0
|
26
|
52.0
| |
|
XPD-Asp312Asn
|
G/G
|
8
|
11.0
|
1
|
12.5
|
0.072
|
| |
G/A
|
65
|
89.0
|
31
|
47.7
| |
|
XPD-Lys751Gln
|
A/A
|
62
|
84.9
|
28
|
45.2
|
0.746
|
| |
A/C or C/C
|
11
|
15.1
|
4
|
36.4
| |
|
XRCC1-Arg399Gln
|
G/G
|
48
|
65.8
|
21
|
43.8
|
0.984
|
| |
G/A or A/A
|
25
|
34.2
|
11
|
44.0
| |
- RR, response rate.
- *p-value for the comparison between response rate and genotypes, based on Pearson's χ 2 test (using Fisher's exact test, if N ≤ 5).
-
#Analysis of the TS-5'UTR VNTR polymorphism with G/C SNP change in 3R allele carriers.
