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Table 2 Effect of modulators of IL-6 synthesis in human colon carcinoma cell clones

From: Clone-specific expression, transcriptional regulation, and action of interleukin-6 in human colon carcinoma cells

  IL-6 secretion by human colon carcinoma cell clones
Addition Caco-2/AQ COGA-1A COGA-13
  pg/ml fold change pg/ml fold change pg/ml fold change
None 4.86 ± 0.49 1.00 ± 0.10 5.49 ± 0.96 1.00 ± 0.17 21.20 ± 1.56 1.00 ± 0.07
indomethacin   0.88 ± 0.36   0.87 ± 0.25   1.02 ± 0.27
PGE2   1.03 ± 0.30   1.08 ± 0.11   1.79 ± 0.20***
1,25-(OH)2D3   1.13 ± 0.14   1.72 ± 0.17**   1.20 ± 0.03*
17β-E2   0.98 ± 0.08   1.26 ± 0.24   0.67 ± 0.12**
IL-1β   2.96 ± 0.26***   0.85 ± 0.13   1035 ± 73***
IL-1β plus indomethacin   3.12 ± 0.28***   0.93 ± 0.28   1147 ± 197***
IL-1β plus PGE2   2.83 ± 0.42***   0.92 ± 0.29   1366 ± 210***
IL-1β plus 17β-E2   2.62 ± 0.24***   0.79 ± 0.12*   1071 ± 33***
  1. Additions to culture medium for 24 h were: indomethacin, 10-6 M; PGE2, 10-7 M; 1,25-(OH)2D3, 10-8 M; 17β-E2, 10-7 M; IL-1β, 5 ng/ml.