Clinicopathologic significance of HIF-1α, p53, and VEGF expression and preoperative serum VEGF level in gastric cancer

Table 2 Correlation between the expression of HIF-1α, p53, VEGF, and preoperative sVEGF level and clinicopathological parameters

		p53			HIF-1α			VEGF			sVEGF
		-	+	P*	-/S	D/V	P*	U	O	P*	Median (range)	P^†
Total		70	44		96	18		48	66		(pg/ml)
Gender
Male	67 (58.8)	37	30	0.106	57	10	0.763	24	43	0.105	82 (6–1076)	0.275
Female	47 (41.2)	33	14		39	8		24	23		158 (7–642)
Age
<60	58 (50.9)	36	22	0.882	49	9	0.935	31	27	0.013	112 (6–622)	0.309
≥ 60	56 (49.1)	34	22		47	9		17	39		121 (6–1076)
Tumor size
<4 cm	47 (41.2)	34	13	0.045	43	4	0.061	19	18	0.761	76 (6–495)	0.002
≥4 cm	67 (58.8)	36	31		53	14		29	38		167 (6–1076)
T stage
T0,1	29 (25.5)	24	5	0.015	28	1	0.001	12	17	0.748	T0–2	0.565
T2	48 (42.1)	28	20		42	6		23	25		103 (6–1076)
T3	31 (27.2)	14	17		23	8		10	21		T3–4
T4	6 (5.3)	4	2		3	3		3	3		165 (8–504)
LN meta
Negative	41 (35.9)	30	11	0.040	38	3	0.051	17	24	0.917	77 (6–477)	0.010
Positive	73 (64.1)	40	33		58	15		31	42		156 (6–1076)
TNM stage
I	42 (36.8)	30	12	0.296	39	3	0.022	17	25	0.840	Stage I-II	0.382
II	25 (21.9)	15	10		21	4		14	11		96 (6–1076)
III	31 (27.2)	13	18		25	6		7	24		Stage III-IV
IV	16 (14.0)	12	4		11	5		10	6		158 (8–504)
Lauren
Intestinal	45 (51.7)	26	19	0.393	39	9	0.387	14	31	0.014	96 (6–1076)	0.294
Diffuse	42 (48.3)	28	14		37	5		24	18		154 (8–633)

P * by χ² test, P ^† by Mann-Whitney U test
HIF-1α: hypoxia-inducible factor 1 alpha, VEGF: vascular endothelial growth factor, sVEGF: preoperative serum vascular endothelial growth factor, LN: lymph node, -/s: negative/superficial pattern, d/v: deep/diffuse/vascular invasion pattern, U: under-expressed, O: over-expressed

ISSN: 1471-2407