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Table 1 Expected vs. non-expected positive endpoints for gestational exposure to cytotoxic drugs.

From: Adjuvant breast cancer chemotherapy during late-trimester pregnancy: not quite a standard of care

Expected effects of transplacental mutagens in late-trimester pregnancies

Expected to be normal

Expected to be abnormal

Congenital malformation rate

Abortion rate

Postnatal apgar indices

Prematurity, stillbirth

Neurologic milestones

Birth weight

Infant sexual/genital development

Adult fertility

Pediatric cancer rate

Adult cancer rate

Transgenerational malformation rate

Transgenerational cancer rate

Short-term cardiovascular function

Long-term cardiovascular function

Learning ability