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Table 1 Expected vs. non-expected positive endpoints for gestational exposure to cytotoxic drugs.

From: Adjuvant breast cancer chemotherapy during late-trimester pregnancy: not quite a standard of care

Expected effects of transplacental mutagens in late-trimester pregnancies
Expected to be normal Expected to be abnormal
Congenital malformation rate Abortion rate
Postnatal apgar indices Prematurity, stillbirth
Neurologic milestones Birth weight
Infant sexual/genital development Adult fertility
Pediatric cancer rate Adult cancer rate
Transgenerational malformation rate Transgenerational cancer rate
Short-term cardiovascular function Long-term cardiovascular function
Learning ability Longevity
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