Table 1 Expected vs. non-expected positive endpoints for gestational exposure to cytotoxic drugs.
From: Adjuvant breast cancer chemotherapy during late-trimester pregnancy: not quite a standard of care
Expected effects of transplacental mutagens in late-trimester pregnancies | |
|---|---|
Expected to be normal | Expected to be abnormal |
Congenital malformation rate | Abortion rate |
Postnatal apgar indices | Prematurity, stillbirth |
Neurologic milestones | Birth weight |
Infant sexual/genital development | Adult fertility |
Pediatric cancer rate | Adult cancer rate |
Transgenerational malformation rate | Transgenerational cancer rate |
Short-term cardiovascular function | Long-term cardiovascular function |
Learning ability | Longevity |