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Table 1 The effects of aspirin or/and PEITC on lung tumorigenesis in Wistar rats treated with NNK

From: Induction of lung lesions in Wistar rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by aspirin and phenethyl isothiocyanate

Group Number of rat Alveolar hyperplasia Alveolar atypical dysplasia
   n Incidence (%) n Incidence (%) [Decreasea]
A. Aspirin 10 6 60.00 1 10.00 [84.00%]
B. PEITC 10 4 40.00 1 10.00 [84.00%]
C. Aspirin + PEITC 10 1 10.00 0 0.00 [100.00%]
D. Positive control 8 2 25.00* 5 62.50**
E. Negative control 9 0 0 0 0
  1. a Compared with the incidence of alveolar atypical dysplasia in group D
  2. *p < 0.05 when compared with negative control group by Fisher's exact probability test.
  3. **p < 0.01 when compared with negative control group by Fisher's exact probability test.
  4. p < 0.05 when compared with positive control group by Fisher's exact probability test.
  5. p < 0.01 when compared with positive control group by Fisher's exact probability test.