Cross-study analysis of gene expression data for intermediate neuroblastoma identifies two biological subtypes

BMC Cancer

Table 3 Enriched GO terms in the category "Biological Process" among the significantly differentially expressed genes.

GO term	Expression	Count {55}	Total {857}	p-value	Corrected p
base-excision repair	-	2	2	0.004	0.307
regulation of kinase activity	+	5	19	0.005	0.307
regulation of protein kinase activity	+	5	19	0.005	0.307
regulation of transferase activity	+	5	20	0.007	0.307
negative regulation of transferase activity	+	3	7	0.007	0.307
negative regulation of protein kinase activity	+	3	7	0.007	0.307
negative regulation of enzyme activity	+	3	8	0.011	0.361
regulation of enzyme activity	+	5	25	0.018	0.361
response to DNA damage stimulus	-	4	17	0.019	0.361
response to endogenous stimulus	-	4	17	0.019	0.361
MAPKKK cascade	+	3	10	0.022	0.361
one-carbon compound metabolism	-	2	4	0.022	0.361
negative regulation of MAPK activity	+	2	4	0.022	0.361
inactivation of MAPK activity	+	2	4	0.022	0.361
M phase of mitotic cell cycle	-	4	18	0.024	0.361
phosphorus metabolism	+	9	68	0.033	0.361
phosphate metabolism	+	9	68	0.033	0.361
M phase	-	4	20	0.034	0.361
regulation of cyclin dependent protein kinase activity	-	2	5	0.036	0.361
glycolysis	-	2	5	0.036	0.361
Wnt receptor signaling pathway	+	2	5	0.036	0.361
oxidative phosphorylation	*	2	5	0.036	0.361

Expression: expression of associated genes in tumors with a favourable prognosis relative to the expression in tumors with unfavourable prognosis; +: up-regulation; -: down-regulation; *: genes show oppositional expression.
Count: number of significant genes associated with given GO term. Total: number of genes in analysis associated with given GO term. The numbers in curly brackets denote the number of genes that could be mapped to GO. Corrected p-values were calculated according to Benjamini and Hochberg as implemented in GOstat.

ISSN: 1471-2407