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Table 4 Stratification analyses for associations between rs3731055 genotypes and risk of lung cancer by selected variables

From: Sequence variations in DNA repair gene XPCis associated with lung cancer risk in a Chinese population: a case-control study

  XPC rs3731055 genotype
Variables Case (n = 967) Control (n = 985) Adjusted OR (95% CI)
  GG AG/AA GG AG/AA GG AG/AA
Total 541 (0.56) 426 (0.44) 512 (0.52) 473 (0.48) 1.00 0.82 (0.68–0.99)*
Age (years)       
   ≤ 60 282 (0.59) 195 (0.41) 240 (0.49) 245 (0.51) 1.00 0.65 (0.50–0.85)**
   > 60 259 (0.53) 231 (0.47) 272 (0.54) 228 (0.46) 1.00 1.03 (0.80–1.34)
Sex       
   Male 420 (0.56) 329 (0.44) 382 (0.52) 353 (0.48) 1.00 0.82 (0.66–1.01)
   Female 121 (0.55) 97 (0.45) 130 (0.52) 120 (0.48) 1.00 0.86 (0.59–1.24)
Smoke status       
   None-smoker 178 (0.60) 119 (0.40) 251 (0.53) 221 (0.47) 1.00 0.74 (0.55–0.99)*
   Smoker 363 (0.54) 307 (0.46) 261 (0.51) 252 (0.49) 1.00 0.90 (0.71–1.13)
< 30 pack-years 136 (0.56) 107 (0.44) 136 (0.52) 127 (0.48) 1.00 0.88 (0.61–1.25)
≥ 30 pack-years 227 (0.53) 200 (0.47) 125 (0.50) 125 (0.50) 1.00 0.91 (0.66–1.24)
Family history of cancer       
   No 435 (0.54) 363 (0.46) 442 (0.52) 416 (0.48) 1.00 0.84 (0.69–1.03)
   Yes 106 (0.63) 63 (0.37) 70 (0.55) 57 (0.45) 1.00 0.71 (0.43–1.18)
  1. a ORs were obtained from a logistic regression model with adjustment for age, sex, residential area, and family history of cancer, and smoking (pack/yr).
  2. *P < 0.05; **P < 0.01.