Figure 3

Nectin-4 expression correlates with basal-like breast markers. Graphical representation of hierarchical clustering results based on expression profiles of 9 proteins in 52 early breast cancer samples measured by immunohistochemistry. Rows: proteins; columns: samples. Protein expression scores are depicted according to a color scale: red, positive staining; green, negative staining; grey, missing data. Dendrograms represent overall similarities in protein expression profiles. Two clusters of proteins are described. A group of proteins, including Nectin-4, which present high expression profile similarities with basal breast markers. A group of proteins, including luminal markers, which negatively correlate with Nectin-4 expression and basal-like markers.