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Table 1 Genotype and allele frequencies of the IL-8 251 A/T and TLR-299 and -399 loci in the non-cancer and cancer groups according to histological findings

From: Assessment of the toll-like receptor 4 Asp299Gly, Thr399Ile and interleukin-8 -251 polymorphisms in the risk for the development of distal gastric cancer

  IL8-251 A/T TLR4 Asp299Gly TLR4Thr399Ile
Group (n) genotype allele genotype allele genotype allele
  AA AT TT *A *T 1,1 1,2 *1 *2 1,1 1,2 *1 *2
Gastritis (207) 42 97 68 0.44 0.56 190 17 0.96 0.04 196 11 0.97 0.03
PUD (29) 4 14 11 0.38 0.62 29 0 1 0 27 2 0.97 0.03
AG + IM (23) 5 10 8 0.43 0.57 20 3 0.93 0.07 23 0 1 0
Gastric cancer (78) 16 47 15 0.51 0.49 72 6 0.96 0.04 77 1 0.99 0.01
diffuse type 8 26 8 0.5 0.5 38 4 0.95 0.05 41 1 0.99 0.01
intestinal type 8 21 7 0.51 0.49 34 2 0.97 0.03 36 0 1 0
H. pylori + (191) 37 90 64 0.43 0.57 175 16 0.96 0.04 181 10 0.97 0.03
Age and gender matched (n = 189) 33 87 69 0.4 0.6 175 14 0.96 0.04 179 10 0.97 0.03
  1. PUD: peptic ulcer disease; AG, atrophic gastritis; IM: intestinal metaplasia